Effects of Sigma-1 Receptor Ligands on Peripheral Nerve Regeneration
Cells, 2022 Peripheral nerve injuries lead to the loss of motor, sensory and autonomic functions in the territories supplied by the injured nerve. Currently, nerve injuries are managed by surgical repair procedures, and there are no effective drugs in the clinic for
Patrick Cottilli +2 more
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The Evaluation of AZ66, A Highly Selective Sigma-1 and Sigma-2 Receptor Antagonist, For Its Anti-Convulsive Effects in C57BL/6 Mice [PDF]
, 2017 The Evaluation of AZ66, A Highly Selective Sigma-1 and Sigma-2 Antagonist, for Anticonvulsive Effects in C57Bl/6 Mice (Under the direction of Lisa Wilson and Dr. Christopher McCurdy) Sigma receptors have become a popular subject for research the past
Stone, Jamie
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PLoS ONE, 2012 Cyproheptadine (CPH) is a histamine- and serotonin-receptor antagonist, and its effects are observed recently in the modulation of multiple intracellular signals.
Yan-Lin He +5 more
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Endothelin-1 Drives Epithelial-Mesenchymal Transition In Hypertensive Nephroangiosclerosis [PDF]
, 2016 BACKGROUND: Tubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin‐1 (ET‐1) activates EMT in cancer cells, but it is not known whether it drives EMT in the kidney.
Belloni, Anna S +13 more
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Sigma-1 receptor concentration in plasma of patients with late-life depression: a preliminary study
Neuropsychiatric Disease and Treatment, 2013 Hideyuki Shimizu,1 Minoru Takebayashi,2 Masayuki Tani,1 Hiroaki Tanaka,1 Bun Yamagata,1 Kenzo Kurosawa,1 Hiroki Yamada,1 Mitsugu Hachisu,3 Kazue Hisaoka-Nakashima,2 Mami Okada-Tsuchioka,2 Masaru Mimura,4 Akira Iwanami11Department of Neuropsychiatry ...
Shimizu H +11 more
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The Sigma-1 Receptor in Cellular Stress Signaling
Frontiers in Neuroscience, 2019 After decades of research, the sigma-1 receptor (Sig-1R)’s structure, and molecular functions are being unveiled. Sig-1R is an integral endoplasmic reticulum (ER) membrane protein which forms an oligomer and binds a variety of psychotropic drugs.
Teruo Hayashi
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Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?
Frontiers in Pharmacology, 2020 Outbreaks of emerging infections, such as COVID-19 pandemic especially, confront health professionals with the unique challenge of treating patients. With no time to discover new drugs, repurposing of approved drugs or in clinical development is likely ...
José Miguel Vela
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Evaluation of Sigma Ligand AZ66 Analgesic Potentiation of Cannabinoids [PDF]
, 2017 Sigma receptors have become a popular subject for research the past few decades, but there is still much mystery behind these receptors and how they work.
Morris, Jacqueline
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TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control [PDF]
, 2014 The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ...
Anholt R +22 more
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Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases
Frontiers in Cellular Neuroscience, 2018 A large body of evidence indicates that sigma-1 receptors (Sig-1R) are important drug targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous system (CNS). In addition to neurons, both cerebral microglia and astrocytes
Jia Jia +3 more
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