Frontiers in Pharmacology, 2020 These unprecedented times have forced the scientific community to gather to face the COVID-19 pandemic. Efforts in diverse directions have been made. A multi-university team has focused on the identification of the host (human) proteins interacting with ...
Carmen Abate +5 more
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Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels [PDF]
, 2005 The relationship between receptor-induced membrane phosphatidylinositol-4'5'-bisphosphate (PIP2) hydrolysis and M-current inhibition was assessed in single-dissociated rat sympathetic neurons by simultaneous or parallel recording of membrane current and ...
Abogadie, FC +6 more
core +1 more source
Allosteric Modulators of Sigma-1 Receptor: A Review
Frontiers in Pharmacology, 2019 Allosteric modulators of sigma-1 receptor (Sig1R) are described as compounds that can increase the activity of some Sig1R ligands that compete with (+)-pentazocine, one of the classic prototypical ligands that binds to the orthosteric Sig1R binding site.
Edijs Vavers +3 more
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Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements [PDF]
, 2010 Label-free biosensor technology based on dynamic mass redistribution (DMR) of cellular constituents promises to translate GPCR signaling into complex optical 'fingerprints' in real time in living cells.
Blattermann, S +16 more
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Formin-dependent TGF-β signaling for epithelial to mesenchymal transition. [PDF]
, 2018 The role of distinct actin filament architectures in epithelial plasticity remains incompletely understood. We therefore determined roles for formins and the Arp2/3 complex, which are actin nucleators generating unbranched and branched actin filaments ...
Aloisio, Francesca M +3 more
core +2 more sources
MoleculesSigma receptors (SRs), including SR1 and SR2 subtypes, have attracted increasing interest in recent years due to their involvement in a wide range of activities, including the modulation of opioid analgesia, neuroprotection, and potential anticancer ...
Daniele Zampieri +7 more
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The Glu102 mutation disrupts higher-order oligomerization of the sigma 1 receptor
Computational and Structural Biotechnology Journal, 2020 The sigma 1 receptor (σ1R) is a unique endoplasmic reticulum membrane protein. Its ligands have been shown to possess therapeutic potential for neurological and substance use disorders among others.
Ara M. Abramyan +6 more
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Cell Reports, 2019 Summary: Sigma-1 receptors (Sig-1Rs) are integral ER membrane proteins. They bind diverse ligands, including psychoactive drugs, and regulate many signaling proteins, including the inositol 1,4,5-trisphosphate receptors (IP3Rs) that release Ca2+ from the
Eugen Brailoiu +8 more
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Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus [PDF]
, 2016 BACKGROUND: Current evidence indicates that estrogens, in particular 17β-estradiol (E2), play a crucial role in the gender bias of autoimmune diseases although the underlying molecular mechanisms have not yet been fully elucidated.
ALESSANDRI, cristiano +11 more
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Effect of sigma-1 receptor activation on corticosterone-induced mitochondrial damage in astrocytes
徐州医科大学学报Objective To investigate the protective effect and mechanism of sigma-1 receptors on corticosterone-induced mitochondrial damage in astrocytes. Methods A corticosterone-induced primary astrocyte damage model was established, and the sigma-1 receptor ...
TANG Weidong +3 more
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