Results 81 to 90 of about 1,199,024 (153)

The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells [PDF]

, 2016
Inhibitors of kinesin spindle protein Eg5 are characterized by pronounced antitumor activity. Our group has recently synthesized and screened a library of 1,3,4-thiadiazoline analogues with the pharmacophoric structure of K858, an Eg5 inhibitor.
CARRADORI, Simone, DE IULIIS, FRANCESCA, giantulli, sabrina, GIUFFRIDA, Anna, MILANA, Bernardina, SALERNO, GERARDO, SCARPA, Susanna, SILVESTRI, Ida, Taglieri, Ludovica   +8 more
core   +1 more source

Effect of SA 4503 on the locomotor stimulatory and discriminative stimulus properties of psychostimulants [PDF]

Title from PDF of title page (University of Missouri--Columbia, viewed on October 25, 2010).The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the ...
Rodvelt, Kelli Renee, 1981-
core   +1 more source

Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor

Molecular Brain, 2018
Cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, exhibits therapeutic potential for various human diseases, including chronic neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, ischemic stroke,
María Rodríguez-Muñoz, Yara Onetti, Elsa Cortés-Montero, Javier Garzón, Pilar Sánchez-Blázquez   +4 more
doaj   +1 more source

Effect of Delayed Stimulation of Sigma-1 Receptor on Embolic Model of Cerebral Ischemia in Rat

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2011
BACKGROUND AND OBJECTIVE: It has been reported that selective sigma receptor agonists have neuroprotective properties in permanent or transient models of middle cerebral artery (MCA) occlusion.
M Allahtavakoli, A Shamsizadeh, N Jarrott   +2 more
doaj  

SIGMA-1 RECEPTOR AGONISM: THE NOVEL TREATMENT OPTION IN RENAL DISEASE [PDF]

, 2017
Hosszú Ádám
core   +1 more source

Editorial: Sigma Receptors

Frontiers in Pharmacology, 2020
Ebru Aydar, Enrique J. Cobos, Tangui Maurice, Ruth D. Murell-Lagnado, Stephen T. Safrany   +4 more
doaj   +1 more source

The Sigma-1 Receptor Agonist Fluvoxamine Is Protective in Hyperglycaemia-Induced Dysfunction of Trabecular Meshwork Cells. [PDF]

Pharmaceuticals (Basel)
Rozsahegyi A, Cserhalmi M, Medveczki T, Buzogany Z, Ruisanchez E, Budai A, Besztercei B, Szabo AJ, Hodrea J, Fekete A.   +9 more
europepmc   +1 more source

Pridopidine, a Potent and Selective Therapeutic Sigma-1 Receptor (S1R) Agonist for Treating Neurodegenerative Diseases. [PDF]

Pharmaceuticals (Basel)
Gershoni Emek N, Tan AM, Geva M, Fekete A, Abate C, Hayden MR.   +5 more
europepmc   +1 more source

Conserved LIR-specific interaction of Sigma-1 receptor and GABARAP. [PDF]

iScience
Baeken MW, Christ M, Schmitt D, Trein W, Nagel H, Clement AM, Körschgen H, Behl C.   +7 more
europepmc   +1 more source

Sigma 1 receptor modulators as a new weapon against multiple sclerosis [PDF]

BioDiscovery, 2017
Simona Collina, Marta Rui, Giacomo Rossino, Serena Della Volpe, Daniela Rossi, Arianna Scuteri, Alessio Malacrida, Guido Cavaletti   +7 more
doaj   +3 more sources