Signal recognition particle binds to translating ribosomes before emergence of a signal anchor sequence. [PDF]
, 2017 The bacterial signal recognition particle (SRP) is part of the machinery that targets ribosomes synthesizing membrane proteins to membrane-embedded translocons co-translationally. Recognition of nascent membrane proteins occurs by virtue of a hydrophobic
Holtkamp, W. +3 more
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Identification of Rock Properties of Rock Wall Cut by Roadheader Based on PSO-VMD-LSSVM
Frontiers in Earth Science, 2022 The problem of low digging efficiency and mining imbalance due to outdated digging technology and low degree of equipment intelligence has long existed in coal mine roadway excavation work.
Pengfei Qi +4 more
doaj +1 more source
Sequential Checkpoints Govern Substrate Selection During Cotranslational Protein Targeting [PDF]
, 2010 Proper protein localization is essential for all cells. However, the precise mechanism by which high fidelity is achieved is not well understood for any protein-targeting pathway.
Rashid, Rumana +3 more
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X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates. [PDF]
PLoS ONE, 2007 The signal recognition particle (SRP) and its conjugate receptor (SR) mediate cotranslational targeting of a subclass of proteins destined for secretion to the endoplasmic reticulum membrane in eukaryotes or to the plasma membrane in prokaryotes ...
Christopher L Reyes +3 more
doaj +1 more source
Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor [PDF]
, 2010 We report the 'early' conformation of the Escherichia coli signal recognition particle (SRP) and its receptor FtsY bound to the translating ribosome, as determined by cryo-EM.
Ban, Nenad +4 more
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The Signal Recognition Particle Database (SRPDB) [PDF]
Nucleic Acids Research, 1999 The signal recognition particle database (SRPDB) is located at the University of Texas Health Science Center at Tyler and includes tabulations of SRP RNA, SRP protein and SRP receptor sequences. The sequences are annotated with links to the primary databases. They are ordered alphabetically or phylogenetically and are available in aligned form.
T, Samuelsson, C, Zwieb
openaire +2 more sources
Signal recognition particle prevents N-terminal processing of bacterial membrane proteins
Nature Communications, 2017 Bacterial proteins are synthesized with formyl-methionine in their N-terminus, but most of them are co-translationally deformylated. Here, the authors show that inner-membrane proteins are protected from deformylation by the binding of the signal ...
Amitabh Ranjan +3 more
doaj +1 more source
Real-time observation of signal recognition particle binding to actively translating ribosomes
eLife, 2014 The signal recognition particle (SRP) directs translating ribosome-nascent chain complexes (RNCs) that display a signal sequence to protein translocation channels in target membranes.
Thomas R Noriega +3 more
doaj +1 more source
Signal Sequence Processing in Rough Microsomes [PDF]
, 1995 Secretory proteins are synthesized with a signal sequence that is usually cleaved from the nascent protein during the translocation of the polypeptide chain into the lumen of the endoplasmic reticulum.
Dobberstein, Bernhard +4 more
core +1 more source
A Distinct Mechanism to Achieve Efficient Signal Recognition Particle (SRP)-SRP Receptor Interaction by the Chloroplast SRP Pathway [PDF]
, 2009 Cotranslational protein targeting by the signal recognition particle (SRP) requires the SRP RNA, which accelerates the interaction between the SRP and SRP receptor 200-fold.
Jaru-Ampornpan, Peera +2 more
core +2 more sources