Results 121 to 130 of about 90,535 (152)

IL-6; signal transducer and activator of transcription 3 (STAT3) [PDF]

Science-Business eXchange, 2009
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[Retracted] microRNA‑195 inhibits cell proliferation in bladder cancer via inhibition of cell division control protein 42 homolog/signal transducer and activator of transcription‑3 signaling. [PDF]

Exp Ther Med
Zhao C, Qi L, Chen M, Liu L, Yan W, Tong S, Zu X.   +6 more
europepmc   +1 more source

Statement of Retraction: Homeodomain-containing gene 10 contributed to breast cancer malignant behaviors by activating Interleukin-6/Janus kinase 2/Signal transducer and activator of transcription 3 pathway. [PDF]

Bioengineered
europepmc   +1 more source

Sirtuin2 suppresses the polarization of regulatory T cells toward T helper 17 cells through repressing the expression of signal transducer and activator of transcription 3 in a mouse colitis model. [PDF]

Immun Inflamm Dis
Ge L, Xu M, Huang M, Liu S, Zhou Z, Xia Z, Zhao Q, Zhou F.   +7 more
europepmc   +1 more source

[Therapeutic mechanism of basic fibroblast growth factor on spinal cord injury in rats based on the Notch/signal transducer and activator of transcription 3 signaling pathway]. [PDF]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
Cao C, Shao G, Zhang M, Li B, Xu H, Zhang H, Qu Y.   +6 more
europepmc   +1 more source

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Signal transducer and activator of transcription 3 signaling in tumor immune evasion

Pharmacology & Therapeutics, 2022
The underlying mechanism of tumor immune evasion is a highly concerning subject for researchers. Increasing evidences reveal that the over-activated signal transducer and activator of transcription 3 (STAT3) is a crucial molecular hub in malignant tumors.
Zhang, Luying, Kuca, Kamil, You, Li, Zhao, Yingying, Musilek, Kamil, Nepovimova, Eugenie, Wu, Qinghua, Wu, Wenda, Adam, Vojtech   +8 more
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Signal Transducer and Activator of Transcription 3 Promotes Leukemogenesis

Blood, 2011
Abstract Abstract 1395 We have previously shown that constitutive activation of the signal transducer and activator of transcription (STAT) 3 protein is associated with worse outcome in patients with acute myeloid leukemia (AML).
Sampa Ghoshal, Michael T Brady, Omar Ustwani, Erin Tracy, Jason Den Haese, Paul K. Wallace, Heinz Baumann, Meir Wetzler   +7 more
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Antitumor Activity of Novel Signal Transducer and Activator of Transcription 3 Inhibitors on Retinoblastoma

Molecular Pharmacology, 2021
Signal transducer and activator of transcription 3 (STAT3) is a plausible therapeutic target in the treatment of retinoblastoma, the most common intraocular malignant tumor in children. STAT3, a transcription factor of several genes related to tumorigenesis, is activated in retinoblastoma tumors as well as other cancers.
Dong Hyun, Jo, Seungbeom, Lee, Eunoo, Bak, Chang Sik, Cho, Young Taek, Han, Kyeojin, Kim, Young-Ger, Suh, Jeong Hun, Kim   +7 more
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Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis

Molecular Carcinogenesis, 2007
AbstractSignal transducer and activator of transcription 3 (Stat3) is one of a family of cytoplasmic proteins that participate in normal cellular responses to cytokines and growth factors as transcription factors. Stat3 modulates various physiological functions including cell survival, cell‐cycle regulation, and angiogenesis through regulation of gene ...
Dae Joon, Kim, Keith S, Chan, Shigetoshi, Sano, John, Digiovanni   +3 more
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Signal transducer and activator of transcription 3 inhibitors: a patent review

Expert Opinion on Therapeutic Patents, 2010
Aberrant activation of signal transducer and activator of transcription (Stat) 3, a member of the STAT family of proteins, is prevalent in numerous human cancers and is now widely recognized as a critical molecular abnormality and a master regulator of tumor processes.
Brent D G, Page, Daniel P, Ball, Patrick T, Gunning   +2 more
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