Results 1 to 10 of about 5,041,480 (330)

Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma [PDF]

, 2017
The pathophysiology of allergic asthma is driven by T-helper 2 (Th2) immune responses following aeroallergen inhalation. The mechanisms that initiate, potentiate and regulate airways allergy are incompletely characterized.
Crompton, Tessa, Furmanski, Anna L., Ross, Rosie, Standing, Ariane S.I., Yánez, Diane C.   +4 more
core   +5 more sources

NEUTROPHIL-LYMPHOCYTE RATIO IN GUILLAIN-BARRÉ SYNDROME: A PROGNOSTIC MARKER TO PREDICT MECHANICAL VENTILATION IN EARLY STAGE OF THE DISEASE

International Journal of Infectious Diseases, 2023
Intro: Guillain-Barré syndrome (GBS), a life-threatening autoimmune disorder, triggered by an antecedent infection mostly by Campylobacter jejuni through molecular mimicry against host nerve gangliosides.
I. Jahan, R. Ahmed, J. Ahmed, S. Khurshid, P. Biswas, I. Upama, Y. Hamid, N. Papri, Q. Mohammad, Z. Islam   +9 more
doaj   +1 more source

Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly

Nature Communications, 2021
Androgen receptor (AR) signaling is regulated by multiple post-translational modifications. Here, the authors identify the writer and reader enzymes for AR ADP-ribosylation and show how they modulate AR signaling output in prostate cancer cells.
Chun-Song Yang, Kasey Jividen, Teddy Kamata, Natalia Dworak, Luke Oostdyk, Bartlomiej Remlein, Yasin Pourfarjam, In-Kwon Kim, Kang-Ping Du, Tarek Abbas, Nicholas E. Sherman, David Wotton, Bryce M. Paschal   +12 more
doaj   +1 more source

ASSOCIATION OF HYPOALBUMINEMIA WITH DISEASE SEVERITY AND MECHANICAL VENTILATION IN GUILLAIN-BARRÉ SYNDROME

International Journal of Infectious Diseases, 2023
Intro: Guillain-Barre syndrome (GBS), an immune-mediated polyneuropathy with variable clinical manifestation, prognosis and outcome. Despite of the proven efficacy of intravenous immunoglobulin (IVIg), 20% patients remain disabled with 2-19% mortality ...
I. Jahan, N. Papri, R. Ahmed, J. Ahmed, S. Khurshid, P. Biswas, I. Upama, Y. Hamid, I. Hasan, A. Rahman, G. Ara, S. Hayat, Q. Mohammad, Z. Islam   +13 more
doaj   +1 more source

GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice

Journal of Neuroinflammation, 2021
Background Repetitive mild traumatic brain injury (mTBI) can result in chronic visual dysfunction. G-protein receptor 110 (GPR110, ADGRF1) is the target receptor of N-docosahexaenoylethanolamine (synaptamide) mediating the anti-neuroinflammatory function
Huazhen Chen, Karl Kevala, Elma Aflaki, Juan Marugan, Hee-Yong Kim   +4 more
doaj   +1 more source

Pan-cancer predictions of transcription factors mediating aberrant DNA methylation

Epigenetics & Chromatin, 2022
Background Aberrant DNA methylation is a hallmark of cancer cells. However, the mechanisms underlying changes in DNA methylation remain elusive. Transcription factors initially thought to be repressed from binding by DNA methylation, have recently ...
Dylane Detilleux, Yannick G. Spill, Delphine Balaramane, Michaël Weber, Anaïs Flore Bardet   +4 more
doaj   +1 more source

Exploring the limits of no backward in time signalling [PDF]

, 2019
We present an operational and model-independent framework to investigate the concept of no-backwards-in-time signaling. We define no-backwards-in-time signaling conditions, closely related to the spatial no-signaling conditions.
Brunner, Nicolas, Guryanova, Yelena, Popescu, Sandu, Short, Anthony J., Silva, Ralph, Skrzypczyk, Paul   +5 more
core   +3 more sources

Dietary fats promote functional and structural changes in the median eminence blood/spinal fluid interface—the protective role for BDNF

Journal of Neuroinflammation, 2018
Background The consumption of large amounts of dietary fats activates an inflammatory response in the hypothalamus, damaging key neurons involved in the regulation of caloric intake and energy expenditure.
Albina F. Ramalho, Bruna Bombassaro, Nathalia R. Dragano, Carina Solon, Joseane Morari, Milena Fioravante, Roberta Barbizan, Licio A. Velloso, Eliana P. Araujo   +8 more
doaj   +1 more source

Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]

, 2019
During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna, Goh, Ryan, Kong, Xiangyu, Liu, Lizhong, Warmflash, Aryeh   +4 more
core   +1 more source

Correction: Abrogation of store-operated Ca2+ entry protects against crystal-induced ER stress in human proximal tubular cells

Cell Death Discovery, 2021
A Correction to this paper has been published: https://doi.org/10.1038/s41420-021-00445 ...
Farai C. Gombedza, Samuel Shin, Yianni L. Kanaras, Bidhan C. Bandyopadhyay   +3 more
doaj   +1 more source