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Retroactive signaling in short signaling pathways. [PDF]
PLoS ONE, 2012 In biochemical signaling pathways without explicit feedback connections, the core signal transduction is usually described as a one-way communication, going from upstream to downstream in a feedforward chain or network of covalent modification cycles. In
Jacques-Alexandre Sepulchre +2 more
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Signaling Pathways in Pregnancy
Cells, 2022 We are pleased to present this Special Issue of Cells, entitled ‘Signaling Pathways in Pregnancy’ [...]
Giovanni Tossetta, Daniela Marzioni
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Signaling Pathways in Gliomas. [PDF]
Genes (Basel)Changes in cell signaling pathways, which in normal conditions determine the maintenance of cell homeostasis and the correctness of its basic processes, may cause the transformation of a normal cell into a cancer cell. Alterations in cellular metabolism leading to oncogenesis are considered to be a hallmark of cancer cells.
Stachyra P, Grzybowska-Szatkowska L.
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Wound healing and signaling pathways [PDF]
Open Life SciencesWound healing is a precisely regulated dynamic process in which signaling pathways play a central role. This article provides a comprehensive review of the signaling pathways involved in wound healing, emphasizing their roles in inflammation, vascular ...
Liu Zhe, Fang Yudong
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International Journal of Molecular Sciences, 2021 p38 Mitogen activated protein kinases (p38MAPK) are a highly evolutionary conserved group of protein kinases, which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration, and tumour formation [...]
Juan José Sanz-Ezquerro, Ana Cuenda
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Conserved immunomodulatory transcriptional networks underlie antipsychotic-induced weight gain
Translational Psychiatry, 2021 Although antipsychotics, such as olanzapine, are effective in the management of psychiatric conditions, some patients experience excessive antipsychotic-induced weight gain (AIWG).
Rizaldy C. Zapata +6 more
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Changes of Signaling Pathways in Hypothalamic Neurons with Aging
Current Issues in Molecular Biology, 2023 The hypothalamus is an important regulator of autonomic and endocrine functions also involved in aging regulation. The aging process in the hypothalamus is accompanied by disturbed intracellular signaling including insulin/insulin-like growth factor-1 ...
Petr M. Masliukov
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Frontiers in Oncology, 2022 Granulocyte colony-stimulating factor receptor (GCSFR) is a critical regulator of granulopoiesis. Studies have shown significant upregulation of GCSFR in a variety of cancers and cell types and have recognized GCSFR as a cytokine receptor capable of ...
Sungjin David Park +5 more
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Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways
Cells, 2022 Over the past two decades, cancer stem cells (CSCs) have emerged as an immensely studied and experimental topic, however a wide range of questions concerning the topic still remain unanswered; in particular, the mechanisms underlying the regulation of ...
Kevina Sonawala +2 more
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Signaling Pathways Regulating Thermogenesis
Frontiers in Endocrinology, 2021 Obesity, an excess accumulation of white adipose tissue (WAT), has become a global epidemic and is associated with complex diseases, such as type 2 diabetes and cardiovascular diseases.
Chihiro Tabuchi, Hei Sook Sul
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