Results 61 to 70 of about 546,808 (280)

The study of selection signature and its applications on identification of candidate genes using whole genome sequencing data in chicken—a review

Poultry Science, 2023
: Chicken is a major source of protein for the increasing human population and is useful for research purposes. There are almost 1,600 distinct regional breeds of chicken across the globe, among which a large body of genetic and phenotypic variations has
Semiu Folaniyi Bello, Raman Akinyanju Lawal, Adeniyi Charles Adeola, Qinghua Nie   +3 more
doaj   +1 more source

The MedSupport Multilevel Intervention to Enhance Support for Pediatric Medication Adherence: Development and Feasibility Testing

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction We developed MedSupport, a multilevel medication adherence intervention designed to address root barriers to medication adherence. This study sought to explore the feasibility and acceptability of the MedSupport intervention strategies to support a future full‐scale randomized controlled trial.
Elizabeth G. Bouchard, Hital Patel, Paula C. Vincent, Justine Kahn, Kira Bona, Thai Hoa Tran, Elisa M. Rodriguez, Kristopher Attwood, Kara M. Kelly   +8 more
wiley   +1 more source

Selection signatures and landscape genomics analysis to reveal climate adaptation of goat breeds

BMC Genomics
Goats have achieved global prominence as essential livestock since their initial domestication, primarily owing to their remarkable adaptability to diverse environmental and production systems.
Weifeng Peng, Yiyuan Zhang, Lei Gao, Wanlu Shi, Zi Liu, Xinyu Guo, Yunxia Zhang, Bing Li, Guoyin Li, Jingya Cao, Mingsheng Yang   +10 more
doaj   +1 more source

Model selection for prognostic time-to-event gene signature discovery with applications in early breast cancer data [PDF]

, 2013
Model selection between competing models is a key consideration in the discovery of prognostic multigene signatures. The use of appropriate statistical performance measures as well as verification of biological significance of the signatures is ...
Ahdesmaeki, Miika, Davison, Timothy S., Harkin, D. Paul, Kennedy, Richard D., Lancashire, Lee, Proutski, Vitali, Wilson, Claire   +6 more
core   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Signatures of Long-Term Balancing Selection in Human Genomes [PDF]

Genome Biology and Evolution, 2017
AbstractBalancing selection maintains advantageous diversity in populations through various mechanisms. While extensively explored from a theoretical perspective, an empirical understanding of its prevalence and targets lags behind our knowledge of positive selection.
Bitarello, Bárbara Domingues, Filippo, Cesare de, Teixeira, João Carlos, Schmidt, Joshua M., Kleinert, Philip, Meyer, Diogo, Andrés, Aida M.   +6 more
openaire   +4 more sources

A bioinformatics workflow for detecting signatures of selection in genomic data

Frontiers in Genetics, 2014
The detection of signatures of selection is now possible on a genome-wide scale in many plant and animal species, and can be performed in a population-specific manner due to the wealth of per-population genome-wide genotype data that is available.
Murray eCadzow, Murray eCadzow, James eBoocock, James eBoocock, Hoang T Nguyen, Hoang T Nguyen, Phillip eWilcox, Phillip eWilcox, Tony R Merriman, Tony R Merriman, Michael A Black, Michael A Black   +11 more
doaj   +1 more source

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Model selection and robust inference of mutational signatures using Negative Binomial non-negative matrix factorization

BMC Bioinformatics, 2023
Background The spectrum of mutations in a collection of cancer genomes can be described by a mixture of a few mutational signatures. The mutational signatures can be found using non-negative matrix factorization (NMF).
Marta Pelizzola, Ragnhild Laursen, Asger Hobolth   +2 more
doaj   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source