Retinal toxicity of long term overdose of sildenafil citrate: A case report [PDF]
American Journal of Ophthalmology Case Reports, 2023 Purpose: To report a case of eye structure changes in a patient with long-term overdose of sildenafil citrate. Observations: A 28-year-old male presented to our outpatient clinic with flare sensation in both eyes for 1 year after taking sildenafil ...
Huichao Yan, Wenzhen Yu
doaj +2 more sources
The effects of sildenafil citrate on intrauterine growth restriction: a systematic review and meta-analysis [PDF]
BMC Pregnancy and Childbirth, 2023 Background An increase in vascular resistance of uterine vessels is associated with intrauterine growth restriction (IUGR). Sildenafil citrate, a phosphodiesterase-5 inhibitor that stabilizes cyclic guanosine monophosphate (cGMP) and increases nitric ...
Yenlik Rakhanova +3 more
doaj +2 more sources
Effect of sildenafil citrate on the cardiovascular system [PDF]
Brazilian Journal of Medical and Biological Research, 2005 Sildenafil citrate is a drug commonly used to manage erectile dysfunction. It is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H -pyrazolo[4,3-d]pyrimidin-5-yl)-4 ethoxyphenyl] sulfonyl]-4-methylpiperazine citrate (C22H30N6O4 S ...
K. Shinlapawittayatorn +2 more
doaj +6 more sources
Bioequivalence Studies of Sildenafil Citrate Orodispersible Film Administered with and without Water vs ViagraⓇ Film-Coated Tablets in Healthy Male Volunteers [PDF]
Current Therapeutic Research, 2023 : Background: Orodispersible film (ODF) formulation offers ease of use, convenience of administration, and other advantages, especially for patients who have difficulty in swallowing or are on liquid restriction compared with conventional oral ...
Andrew Shaw, PhD +10 more
doaj +2 more sources
Development of a Sildenafil Citrate Microemulsion-Loaded Hydrogel as a Potential System for Drug Delivery to the Penis and Its Cellular Metabolic Mechanism [PDF]
Pharmaceutics, 2020 Sildenafil citrate is used to treat mild to moderate erectile dysfunction and premature ejaculation. However, it has low oral bioavailability, numerous adverse effects, and delayed onset of action.
Apichart Atipairin +5 more
doaj +2 more sources
Development and Validation of a Simple, Green Infrared Spectroscopic Method for Quantitation of Sildenafil Citrate in Siloflam Tablets of Unknown Manufacturing Formula [PDF]
Journal of Analytical Methods in Chemistry, 2021 A simple, easy-to-implement, and green infrared spectroscopic method was developed and validated for the quantitative determination of sildenafil citrate in tablets of unknown manufacturing formula. Homogenized tablet powder with known mass content (%, m/
Van Trung Bui +3 more
doaj +2 more sources
Viagra® (sildenafil citrate) and ophthalmology
Progress in Retinal and Eye Research, 2002 Viagra (sildenafil citrate) improves penile erections in men with erectile dysfunction (ED) by selectively inhibiting cGMP-specific phosphodiesterase type 5 (PDE5), which is present in all vascular tissue. It also exerts a minor inhibitory action against PDE6, which is present exclusively in rod and cone photoreceptors.
Alan M. Laties, Eberhart Zrenner
openalex +4 more sources
The Weekend Drug; Recreational Use of Sildenafil Citrate and Concomitant Factors: A Cross-Sectional Study [PDF]
Frontiers in Medicine, 2021 Background: Men who use erectile dysfunction medications for recreational purposes may be at increased risk of becoming psychologically dependent, which in turn could lead to psychogenic-based erectile dysfunction symptoms.
Berhanemeskel Weldegerima Atsbeha +5 more
doaj +2 more sources
Ventricular tachycardia after administration of sildenafil citrate: a case report [PDF]
Journal of Medical Case Reports, 2007 Background It has not previously been reported that sildenafil citrate causes malignant arrhythmias in humans. Case presentation A 41-year-old man developed sustained ventricular tachycardia following sildenafil citrate administration.
Rasmussen Jeppe G +2 more
doaj +2 more sources
Pharmacokinetic profile of sildenafil citrate in healthy Middle Eastern Males: Comparison with other ethnicities [PDF]
Saudi Pharmaceutical Journal, 2021 Aim: 1) To investigate the pharmacokinetic profile of sildenafil citrate in Middle Eastern males and, 2) To highlight the impact of ethnicity on its pharmacokinetics parameters through comparing Middle Eastern data to the data estimated from different ...
Abdulrahman Alwhaibi +5 more
doaj +2 more sources