Results 31 to 40 of about 10,448 (268)

Effect of sildenafil in cavernous arteries of patients with erectile dysfunction

International Brazilian Journal of Urology, 2003
INTRODUCTION: Sildenafil citrate is a type 5 phosphodiesterase inhibitor, which has demonstrated excellent results in the treatment of erectile dysfunction.
Joaquim A Claro, Sérgio F Ximenes, Archimedes Nardozza Jr, Enrico Andrade, Leonardo Messina, Miguel Srougi   +5 more
doaj   +1 more source

Oral bioavailability and pharmacokinetics of sildenafil citrate dry foam tablets in rats

Cogent Medicine, 2018
Sildenafil has low water solubility and oral bioavailability. Dry foam formulations of solid dosage forms of poorly water-soluble drugs may exhibit improved dissolution and bioavailability.
Somchai Sawatdee, Apichart Atipairin, Attawadee Sae Yoon, Teerapol Srichana, Narumon Changsan, Tan Suwandecha, Wirot Chanthorn, Atchara Phoem   +7 more
doaj   +1 more source

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. [PDF]

, 2015
Blocking Plasmodium falciparum transmission to mosquitoes has been designated a strategic objective in the global agenda of malaria elimination. Transmission is ensured by gametocyte-infected erythrocytes (GIE) that sequester in the bone marrow and at ...
A Dawn, A Heiber, A Merckx, A Pantaleo, A Sudo, AE Bianco, Audrey Lorthiois, Bernina Naissant, C Lavazec, C Lavazec, C Syin, Catherine Lavazec, CJ Taylor, D Yokoyama, DA Baker, David A. Baker, DK Muhia, Dominique Soldati-Favre, Donatella Taramelli, E Farfour, E Lasonder, E Ling, Eloise Thompson, F Hawking, F Silvestrini, F Silvestrini, Florence Breil, Florian Dupuy, G Deplaine, Ghania Ramdani, Gordon Langsley, HM Taylor, I Koshino, J Bain, K Leykauf, Kenneth Vernick, KM Tang, L Chen, L McRobert, L Wentzinger, LK Read, M Aingaran, M Boolell, M Hliscs, M Tiburcio, M Tiburcio, ME Smalley, MJ Lopez-Barragan, MK Dearnley, MW Dixon, N Goto, N Mohandas, Odile Mercereau-Puijalon, QL Fivelman, R Aguilar, R Joice, RE Sinden, RE Sinden, RL Coppel, Ross Cummings, RW Moon, S D'Alessandro, S Kunz, S Sanyal, SM Knebel, SP Davies, SP Kim, T Bousema, T Harrison, T Ono, T Seebeck, W Trager, WB Smith 2nd, Yoann Duffier, Yolanda Corbett   +74 more
core   +8 more sources

Effects and mechanisms of action of sildenafil citrate in human chorionic arteries

Reproductive Biology and Endocrinology, 2009
Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for ...
Lynch Tadhg, O'Toole Daniel, Maharaj Chrisen H, Carney John, Jarman James, Higgins Brendan D, Morrison John J, Laffey John G   +7 more
doaj   +1 more source

If We Cannot Use Nitric Oxide for Newborn Persistent Pulmonary Hypertension, is Oral Sildenafil Therapeutic? A Single-center Experience

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: Persistent pulmonary hypertension is still an issue in newborn period with different treatment strategies. In this study, we aimed to evaluate the three-year experience of a neonatal intensive care unit on use of sildenafil citrate for ...
Selçuk Gürel
doaj   +1 more source

The use of high performance anion exchange chromatography for the detection of counterfeit pharmaceutical products using the excipient content as a marker [PDF]

, 2015
The aim of the investigation described here was to examine the differences between genuine and counterfeit pharmaceutical products through the development of an analytical method capable of rigorously identifying the sugar-based excipients.
Beasley, Emma, Coleman, Tyler, Suman, Mandeesh   +2 more
core   +2 more sources

Micro-recanalization in a biodegradable graft for reconstruction of the vas deferens is enhanced by sildenafil citrate [PDF]

, 2010
This study investigated the effect of sildenafil citrate on micro-recanalization and neovascularization, which were previously demonstrated in a rat model using biodegradable grafts (BGs) for vas deferens reconstruction. A total of 24 male rats underwent
Ariza, Carlos, DeYoung, Barry, Griffith, Thomas, Holoch, Peter, Mallapragada, Surya, Mallapragada, Surya, Wald, Moshe   +6 more
core   +3 more sources

Efficacy and safety of flexible-dose oral sildenafil citrate (Viagra((R))) in the treatment of erectile dysfunction in Brazilian and Mexican men [PDF]

, 2002
A 12-week, double-blind, placebo-controlled, multicenter study evaluated the efficacy and safety of flexible-dose sildenafil citrate (Viagra((R))) treatment (25, 50 or 100 mg) in Brazilian and Mexican men with erectile dysfunction (ED) of broad-spectrum ...
Bertero, E., Claro, Joaquim, Damião, Ronaldo, Faria, Geraldo, Fregonesi, Adriano, Glina, S., Jaspersen, J., Mattos, Demerval, Mendoza, Antonio, Rocha, Luiz Carlos, Sotomayor, Mariano, Teloken, Cláudio, Ugarte, F., Ureta, S., Zonana, E.   +14 more
core   +1 more source

Response to pulmonary arterial hypertension drug therapies in patients with pulmonary arterial hypertension and cardiovascular risk factors. [PDF]

, 2014
The age at diagnosis of pulmonary arterial hypertension (PAH) and the prevalence of cardiovascular (CV) risk factors are increasing. We sought to determine whether the response to drug therapy was influenced by CV risk factors in PAH patients. We studied
Charalampopoulos, A, Connolly, SB, Davies, RJ, Gibbs, JS, Gin-Sing, W, Grapsa, J, Howard, LS, Nihoyannopoulos, P, Tzoulaki, I, Wilkins, MR   +9 more
core   +1 more source

Why sildenafil and sildenafil citrate monohydrate crystals are not stable?

Saudi Pharmaceutical Journal, 2015
Sildenafil citrate was crystallized by various techniques aiming to determine the behavior and factors affecting the crystal growth. There are only 2 types of sildenafil obtaining from crystallization: sildenafil (1) and sildenafil citrate monohydrate (2).
Chaveng Pakawatchai, Somchai Sawatdee, Hirihattaya Phetmung, Teerapol Srichana, Kwanjai Nitichai   +4 more
openaire   +2 more sources