Results 31 to 40 of about 3,731 (172)

Astragaloside IV alleviates hypoxic pulmonary hypertension by inhibiting RELM‐β to reduce PINK1/Parkin‐mediated mitophagy in pulmonary artery smooth muscle cells (PASMCs)

British Journal of Pharmacology, Volume 182, Issue 24, Page 5933-5952, December 2025.
Background and Purpose Hypoxic pulmonary hypertension (HPH) is a chronic disorder marked by irreversible pulmonary vascular remodelling (PVR) and pulmonary artery smooth muscle cell (PASMC) dysfunction. Astragaloside IV (AS‐IV), a natural saponin from Astragalus, shows potential in HPH management. This study explores AS‐IV's protective effect on PVR in
Rongzhen Ding, Haiping Xie, Shuliu Sang, Li Qin, Yinhui Sun, Chao Zhang, Jian Yi, Hui Liu, Jianmin Fan, Guoran Peng, BeiBei Cheng, Lan Song, Aiguo Dai   +12 more
wiley   +1 more source

An overview on sildenafil and female infertility

Indian Journal of Health Sciences and Biomedical Research KLEU, 2016
Endometrial thickness (EM) is one of the strongest predictors of implantation rate and ongoing pregnancy success rate. The endometrial growth is dependent on the uterine blood flow and angiogenesis.
Jyoti M Benni, Paragouda A Patil
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Beliefs and Social Norms About Sildenafil Citrate (Viagra) Misuse and Perceived Consequences Among Houstonian Teenage Males

American Journal of Men's Health, 2007
In the current study, a qualitative approach was used to investigate relevant beliefs and norms associated with sildenafil citrate (Viagra) consumption, initiation, and perceived consequences.
Ronald J. Peters DrPH, MS, Regina J. Johnson DrPH, MSN, RN, Steve Kelder PhD, Angela F. Meshack DrPH, Troy Jefferson BA   +4 more
doaj   +1 more source

“I'd rather die”: Patients' will and decision‐making practice in Japanese community psychiatry

Medical Anthropology Quarterly, Volume 39, Issue 4, December 2025.
Abstract Recent mental health reforms have embraced patient autonomy and shared decision‐making, where care unfolds through collaboration between clinicians and patients. However, how decision‐making can improve in marginalized psychiatric clinics remains unclear.
Yuto Kano
wiley   +1 more source

The Survey of Angiogenesis and Myometrial Thickness of Preimplantation Mouse Uterine in Natural Cycle in those Received Human Menopausal Gonadotropin-Human Chorionic Gonadotropin (HMG–HCG) and Sildenafil Citrate

مجله دانشکده پزشکی اصفهان, 2017
Background: Uterus myometrium contractions play crucial role in break or successful embryo implantation. Furthermore, efficient myometrial angiogenesis is important event for supplying endometrium blood.
Gholamreza Dashti, Ariubarzan Farhadi, Mohammad Javad Saeedi-Borujeni, Bahman Rashidi   +3 more
doaj  

Antimicrobial, Synergistic, and Antibiofilm Activity of Sildenafil Against Pseudomonas aeruginosa: Preliminary Studies

Applied Sciences
The present study tested sildenafil citrate as an example of pharmacological repositioning against the opportunistic pathogen Pseudomonas aeruginosa, known for its potent biofilm formation.
Thais de Moraes Barin, Camilla Filippi dos Santos Alves, Cristiane Antunes Teixeira, Camila Marina Verdi, Kelly Schneider Moreira, Thiago Burgo, Vitória Fernanda Belmonte Novais, Rodrigo de Almeida Vaucher, Roberto Christ Vianna Santos   +8 more
doaj   +1 more source

Electroretinography and immunohistochemistry of retina in rabbits treated with sildenafil citrate

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2015
Sildenafil citrate is a type-5 phosphodiesterase inhibitor (PDE-5), able to inhibit type-6 phosphodiesterase (PDE-6) as well, providing clinical benefits and paraeffects, some of them potentially related to the retina.
A.V.C. Amaral, G.A. Silva, A.P.A. Costa, K.S. Oliveira, P. Jordão, A.P. Ribeiro, R. Renzo, J.L. Laus   +7 more
doaj   +1 more source

Real‐World Study on the Impact of Novel Coronavirus Infection on Male Erectile Function

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT This study aims to examine the impact of novel coronavirus (COVID‐19) infection on male erectile function and to identify potential influencing factors. Male participants aged 18–65 years from Beijing and Shanghai were included in the study. A post‐COVID‐19 sexual function questionnaire was utilized for data collection.
Chuhong Chen, Zihan Zhou, Zhecheng Zhang, Qingtong Yi, Rujian Zhu, Xujun Xuan, Dong Liu   +6 more
wiley   +1 more source