Results 71 to 80 of about 206,958 (317)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Silent Body and Reclusiveness for Freedom and Madness: A Reading of Maria Teresa Horta’s Ambas as mãos sobre o corpo and Ema

open access: yesAbriu: Estudos de Textualidade do Brasil, Galicia e Portugal, 2012
This article offers an analysis of two of Maria Teresa Horta’s narrative titles Ambas as mãos sobre o corpo and Ema, where we observe that women were historically conditioned and trapped within a silent, submissive, reclusive and obedient web, under the ...
Mônica Sant’Anna
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

REPRESENTANTS OF THE SITUATION OF SILENCE AND WITHDRAWAL FROM IT

open access: yesВестник Кемеровского государственного университета, 2015
The research focuses on silence as a major component of verbal communication. The object of the research is contexts containing markers of silence. The research is aimed to distinguish the language means used by writers to describe the situation of ...
S. V. Valiulina
doaj  

Silence and ritual response in Igbo discourse

open access: yesStudies in African Linguistics, 1989
This study discusses silence and ritual response as behavioural acts that are communicatively significant among the Igbos of Nigeria. Using actual discourse samples, the appropriate and inappropriate uses of these acts as well as their functions are ...
Bertram A. Okolo
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

When Silence Speaks: An Analysis of Silence as a Communication Tool through Taylor Swift [PDF]

open access: yes
openThe thesis investigates the role of silence as a strategic communication tool in celebrity politics. Silence can convey several different messages, inciting speculation, and shaping narratives.
GARCIA-ARBÓS I MATA, MARIONA
core  

Women choosing silence relationality and transformation in spiritual practice

open access: yes, 2020
"Silence is long-established as a spiritual discipline amongst people of faith. However, its examination tends to focus on depictions within texts emerging from religious life and the development of its practices. Latterly, feminist theologians have also
Woolley, Alison 1973-
core  

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