Results 101 to 110 of about 31,498 (300)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
BMC NursingAim This study aimed to assess the relationship between compulsory citizenship behavior and nurses’ silence. Methods A descriptive cross-sectional online study was conducted in October 2023, targeting 402 nurses working in Yichang Central People’s ...
Zifeng Li +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Theorizing [dis]engagement, voice and silence in a community-based forest management organization
, 2015 This study examined engagement, disengagement, voice and silence in CFP-BA (Community Forestry Program-Beneficiaries Association), a community-based forest resource management organization, in Biliran Province, Philippines.
Gerona, Maria Anabelle D
core
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Practicing Silence about Staff Violence in Residential Care for Children with Disabilities
Social Work and Society, 2021 This article analyzes the practice of silence about staff violence in educational institutions. It examines a team that, for many years, legitimized its use of violence against children with disabilities in residential care by declaring it to be a ...
Friederike Lorenz
doaj
Silence in an organization and trust in an organization – the role of the employee’s gender
Scientific Papers of Silesian University of Technology. Organization and Management SeriesPurpose: The purpose of the work is to analyze the relationship between silence in the organization and trust in the organization, considering the differentiation of silence in the organization and the role of gender employees. Design/methodology/approach: The empirical material was obtained through a questionnaire survey.
openaire +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source