Results 121 to 130 of about 422,762 (346)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
In vivo imaging of siRNA electrotransfer and silencing in different organs
, 2007 RNA interference (RNAi)-mediated gene silencing approaches appear very promising for therapies based on the targeted inhibition of disease-relevant genes. The major hurdle to the therapeutic development of RNAi strategies remains however the efficient delivery of the RNAi-inducing molecules, the short interfering RNAs (siRNAs) and short hairpin RNAs ...
Golzio Muriel +6 more
openaire +3 more sources
Investigation of Organizational Silence from the Perspective of Imam Ali (AS) [PDF]
اسلام و مدیریتStressing on the sermons and letters of Imam Ali (AS), this paper was to investigate the concept of organizational silence in a comparative study between Islamic perspective and Western views.
doaj
Discover PsychologyWhile employee voice address challenges, silence impedes organizational adaptability. Moving beyond previous dichotomous approaches, follower groups were identified based on their voice and silence behaviors, and various predictive and outcome variables ...
Barnabás Buzás, Klára Faragó
doaj +1 more source
Resisting Hegemony through Noise [PDF]
, 2019 This essay examines the cultural phenomena of noise in its perceived social constructions and demonstrates its emergence as a form of resistance against prevailing dominant hegemonic codes of culture.
Robertson, Casey
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
BMC NursingAim This study aimed to assess the relationship between compulsory citizenship behavior and nurses’ silence. Methods A descriptive cross-sectional online study was conducted in October 2023, targeting 402 nurses working in Yichang Central People’s ...
Zifeng Li +6 more
doaj +1 more source
Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma
Frontiers in Oncology, 2018 Objective: Cathepsin D (CTSD) is a pivotal orchestrator in the occurrence and development of tumors. Recently, CTSD was detected in salivary adenoid cystic carcinoma (SACC).
Mei Zhang +26 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source