Results 1 to 10 of about 14,059 (132)

Immune Control of AIDS Progression by an Adenovirus‐Based Therapeutic Vaccination in Acute Simian Immunodeficiency Virus‐Infected Macaques [PDF]

MedComm
Therapeutic vaccinations that enhance human immunodeficiency virus (HIV)‐specific immunity hold promise for reducing reliance on antiretroviral therapy (ART).
Yizi He, Chunxiu Wu, Fengling Feng, Zijian Liu, Xugang Zhang, Qing Yang, Zhe Chen, Minjuan Shi, Ziyu Wen, Yichu Liu, Fengyu Hu, Linghua Li, Caijun Sun, Ling Chen, Pingchao Li   +14 more
doaj   +3 more sources

Chronic alcohol accentuates simian acquired immunodeficiency syndrome-associated wasting. [PDF]

Alcohol Clin Exp Res, 2008
Background:  Survival following human immunodeficiency virus (HIV) infection has improved significantly following the advent of highly active antiretroviral therapy. A large percentage of HIV‐infected patients consume and abuse alcohol. Erosion of lean body mass is an important contributing factor to patient morbidity and mortality, and is a common ...
Molina PE, Lang CH, McNurlan M, Bagby GJ, Nelson S.   +4 more
europepmc   +4 more sources

Minimally Modified HIV-1 Infection of Macaques: Development, Utility, and Limitations of Current Models [PDF]

Viruses
Nonhuman primate (NHP) studies that utilize simian immunodeficiency virus (SIV) to model human immunodeficiency virus (HIV-1) infection have proven to be powerful, highly informative research tools.
Manish Sharma, Mukta Nag, Gregory Q. Del Prete   +2 more
doaj   +2 more sources

Advances in SIV/SHIV Non-Human Primate Models of NeuroAIDS

Pathogens, 2021
Non-human primates (NHPs) are the most relevant model of Acquired Immunodeficiency Syndrome (AIDS) and neuroAIDS, being of great importance in explaining the pathogenesis of HIV-induced nervous system damage.
Sonia Moretti, Sara Virtuoso, Leonardo Sernicola, Stefania Farcomeni, Maria Teresa Maggiorella, Alessandra Borsetti   +5 more
doaj   +1 more source

The default mode network is affected in the early stage of simian immunodeficiency virus infection: a longitudinal study

Neural Regeneration Research, 2023
Acquired immune deficiency syndrome infection can lead to cognitive dysfunction represented by changes in the default mode network. Most recent studies have been cross-sectional and thus have not revealed dynamic changes in the default mode network ...
Zhen-Chao Tang, Jiao-Jiao Liu, Xue-Tong Ding, Dan Liu, Hong-Wei Qiao, Xiao-Jie Huang, Hui Zhang, Jie Tian, Hong-Jun Li   +8 more
doaj   +1 more source

Autophagy Induced by Simian Retrovirus Infection Controls Viral Replication and Apoptosis of Jurkat T Lymphocytes

Viruses, 2020
Autophagy and apoptosis are two important evolutionarily conserved host defense mechanisms against viral invasion and pathogenesis. However, the association between the two pathways during the viral infection of T lymphocytes remains to be elucidated ...
Jingting Zhu, Lingyan Yang, Qibo Zhang, Jia Meng, Zhi-Liang Lu, Rong Rong   +5 more
doaj   +1 more source

Immunodeficiency viruses and prion disease [PDF]

Primate Biology, 2015
Two threatening human diseases have emerged during the past 35 years. Human immunodeficiency virus (HIV) was transmitted from non-human primates – e.g., the chimpanzee to humans – and then spread into populations all over the world.
W. Bodemer
doaj   +1 more source

Evolution of drug resistance drives destabilization of flap region dynamics in HIV-1 protease

Biophysical Reports, 2023
The HIV-1 protease is one of several common key targets of combination drug therapies for human immunodeficiency virus infection and acquired immunodeficiency syndrome.
Madhusudan Rajendran, Maureen C. Ferran, Leora Mouli, Gregory A. Babbitt, Miranda L. Lynch   +4 more
doaj   +1 more source

Analysis of the In Vivo Turnover of CD4+ T-Cell Subsets in Chronically SIV-Infected Sooty Mangabeys. [PDF]

PLoS ONE, 2016
Aberrant turnover of memory CD4+ T-cells is central to Acquired Immunodeficiency Syndrome (AIDS) progression. Understanding the relationship between the turnover of CD4+ subsets and immunological homeostasis during simian immunodeficiency virus (SIV ...
Alexandra M Ortiz, Diane G Carnathan, Joana Yu, Katherine M Sheehan, Peter Kim, Arnold Reynaldi, Thomas H Vanderford, Nichole R Klatt, Jason M Brenchley, Miles P Davenport, Guido Silvestri   +10 more
doaj   +1 more source

Learning to Be Elite: Lessons From HIV-1 Controllers and Animal Models on Trained Innate Immunity and Virus Suppression

Frontiers in Immunology, 2022
Although antiretroviral therapy (ART) has drastically changed the lives of people living with human immunodeficiency virus-1 (HIV-1), long-term treatment has been associated with a vast array of comorbidities. Therefore, a cure for HIV-1 remains the best
Sho Sugawara, R. Keith Reeves, Stephanie Jost   +2 more
doaj   +1 more source