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Antiviral effect of novel purine conjugate LAS-131 against Herpes simplex virus type 1 (Herpesviridae: Alphaherpesvirinae: Simplexvirus: Human alphaherpesvirus 1) in vitro [PDF]
Вопросы вирусологии, 2021 Introduction. Herpes simplex viruses type 1 (HSV-1) are extremely widespread throughout the world and, similar to other herpesviruses, establish lifelong persistent infection in the host.
V. L. Andronova +5 more
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Вопросы вирусологии, 2021 Introduction. A significant increase in the incidence of various forms of herpesvirus infection (HVI) determines the need to search for new approaches to the modification of one of the basic antiviral drugs aciclovir (ACV) and its dosage forms to improve
L. M. Alimbarova +3 more
doaj +6 more sources
Вопросы вирусологии, 2020 RETRACTED Herpes simplex viruses types 1 (HSV-1) and 2 (HSV-2) are among the most common viruses in the human population. The clinical manifestations of HSV infection vary widely, which necessitates reliable molecular methods for the timely diagnosis of ...
O. V. Sergeyev +2 more
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Вопросы вирусологии, 2020 Introduction. One of the most urgent problem of modern medicine is the fight against the disease caused by the Human Immunodeficiency Virus (HIV) – HIV infection. The chemical compounds have improved the situation for infected people, but they are toxic,
D. N. Nosik +7 more
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Вопросы вирусологииIntroduction. Herpes simplex virus type 1 (HSV-1) is one of the most common human viral infections and has a double-stranded DNA genome belonging to the Herpesviridae family.
Jalil B. Mays +2 more
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Intrinsically disordered regions are abundant in simplexvirus proteomes and display signatures of positive selection [PDF]
Virus Evolution, 2020 Abstract Whereas the majority of herpesviruses co-speciated with their mammalian hosts, human herpes simplex virus 2 (HSV-2, genus Simplexvirus) most likely originated from the cross-species transmission of chimpanzee herpesvirus 1 to an ancestor of modern humans. We exploited the peculiar evolutionary history of HSV-2 to investigate the
Mozzi A +5 more
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Phylogeographic analysis reveals an ancient East African origin of human herpes simplex virus 2 dispersal out-of-Africa [PDF]
Nature Communications, 2022 AbstractHuman herpes simplex virus 2 (HSV-2) is a ubiquitous, slowly evolving DNA virus. HSV-2 has two primary lineages, one found in West and Central Africa and the other found worldwide. Competing hypotheses have been proposed to explain how HSV-2 migrated out-of-Africa (i)HSV-2 followed human migration out-of-Africa 50-100 thousand years ago, or (ii)
Havens, Jennifer +5 more
openaire +7 more sources
Characteristics of the pulmonary microbiota in patients with mild and severe pulmonary infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 BackgroundLung infection is a global health problem associated with high morbidity and mortality and increasing rates of hospitalization. The correlation between pulmonary microecology and infection severity remains unclear.
Danting Zhan +6 more
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Antiviral Efficacy of Coridothymus capitatus Essential Oil Against HSV-1 and HSV-2 [PDF]
LifeCoridothymus capitatus is a perennial herb with aromatic leaves and flowers, distinct from Thymus vulgaris in its chemical composition, resulting in a unique Thymus Essential Oil (TEO).
Virginia Fuochi +3 more
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CRISPR/Cas9 Reduces Viral Load in a BALB/c Mouse Model of Ocular Herpes Infection [PDF]
BiomedicinesBackground/Objectives: Simplexvirus humanalpha1 (HSV-1) can cause herpetic keratitis, which is the most common cause of infectious blindness in developed countries.
Luiza Silveira Garcia +6 more
doaj +2 more sources