Results 1 to 10 of about 7,543 (128)

Nasopharyngeal virome analysis of COVID-19 patients during three different waves in Campania region of Italy. [PDF]

J Med Virol, 2022
Abstract From December 2019, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has spread rapidly, leading to a global pandemic. Little is known about possible relationships between SARS‐CoV‐2 and other viruses in the respiratory system affecting patient prognosis and outcomes.
Ferravante C, Sanna G, Melone V, Fromentier A, Rocco T, D'Agostino Y, Lamberti J, Alexandrova E, Pecoraro G, Pagliano P, Astorri R, Manzin A, Weisz A, Giurato G, Galdiero M, Rizzo F, Rizzo F, Franci G.   +17 more
europepmc   +2 more sources

Rapid taxonomic categorization of short, abundant virus sequences for ecological analyses. [PDF]

Ecol Evol
We sampled 1086 bats from two, adjacent Puerto Rican caves and tested them for infection by herpesviruses, resulting in 3131 short, viral sequences. Using percent identity of nucleotides and a machine learning algorithm (affinity propagation), we categorized herpesviruses into 43 operational taxonomic units (OTUs).
Sjodin AR, Willig MR, Rodríguez-Durán A, Anthony SJ.   +3 more
europepmc   +2 more sources

Discovery of Novel Herpes Simplexviruses in Wild Gorillas, Bonobos, and Chimpanzees Supports Zoonotic Origin of HSV-2. [PDF]

Mol Biol Evol, 2021
Viruses closely related to human pathogens can reveal the origins of human infectious diseases. Human herpes simplexvirus type 1 (HSV-1) and type 2 (HSV-2) are hypothesized to have arisen via host-virus codivergence and cross-species transmission.
Wertheim JO, Hostager R, Ryu D, Merkel K, Angedakin S, Arandjelovic M, Ayimisin EA, Babweteera F, Bessone M, Brun-Jeffery KJ, Dieguez P, Eckardt W, Fruth B, Herbinger I, Jones S, Kuehl H, Langergraber KE, Lee K, Madinda NF, Metzger S, Ormsby LJ, Robbins MM, Sommer V, Stoinski T, Wessling EG, Wittig RM, Yuh YG, Leendertz FH, Calvignac-Spencer S.   +28 more
europepmc   +5 more sources

Novel Alpha-, Beta-, and Gammaherpesviruses in Neotropical Carnivores of Brazil. [PDF]

Transbound Emerg Dis
The knowledge regarding infectious agents affecting wildlife is crucial for species’ conservation. We hypothesized that herpesviruses are present in wild Neotropical carnivores. Herein, we used DNA polymerase and glycoprotein B broad‐spectrum PCRs to molecularly survey the presence of herpesviruses in spleen and/or lung samples of 53 wild Neotropical ...
Ewbank AC, Catão-Dias JL, Navas-Suarez PE, Duarte-Benvenuto A, Zamana-Ramblas R, Ferreira-Machado E, Lial HC, Ibáñez-Porras P, Sacristán I, Sacristán C.   +9 more
europepmc   +2 more sources

Antiviral effect of novel purine conjugate LAS-131 against Herpes simplex virus type 1 (Herpesviridae: Alphaherpesvirinae: Simplexvirus: Human alphaherpesvirus 1) in vitro [PDF]

Problems of Virology, 2021
Introduction. Herpes simplex viruses type 1 (HSV-1) are extremely widespread throughout the world and, similar to other herpesviruses, establish lifelong persistent infection in the host. Reactivating sporadically, HSV-1 elicits recurrences in both immunocompetent and immunocompromised individuals and can cause serious diseases (blindness, encephalitis,
Andronova, V. L., Galegov, G. A., Musiyak, V. V., Vozdvizhenskaya, O. A., Levit, G. L., Krasnov, V. P.   +5 more
openaire   +5 more sources

Intrinsically disordered regions are abundant in simplexvirus proteomes and display signatures of positive selection [PDF]

Virus Evolution, 2020
Abstract Whereas the majority of herpesviruses co-speciated with their mammalian hosts, human herpes simplex virus 2 (HSV-2, genus Simplexvirus) most likely originated from the cross-species transmission of chimpanzee herpesvirus 1 to an ancestor of modern humans. We exploited the peculiar evolutionary history of HSV-2 to investigate the
Mozzi A, Forni D, Cagliani R, Clerici M, Pozzoli U, Sironi M   +5 more
openaire   +5 more sources

Phylogeographic analysis reveals an ancient East African origin of human herpes simplex virus 2 dispersal out-of-Africa [PDF]

Nature Communications, 2022
AbstractHuman herpes simplex virus 2 (HSV-2) is a ubiquitous, slowly evolving DNA virus. HSV-2 has two primary lineages, one found in West and Central Africa and the other found worldwide. Competing hypotheses have been proposed to explain how HSV-2 migrated out-of-Africa (i)HSV-2 followed human migration out-of-Africa 50-100 thousand years ago, or (ii)
Jennifer L. Havens, Sébastien Calvignac-Spencer, Kevin Merkel, Sonia Burrel, David Boutolleau, Joel O. Wertheim   +5 more
openaire   +5 more sources

Genus Simplexvirus: Life cycle

Acta Microbiologica Bulgarica, 2023
The two same-name members of the subfamily Alphaherpesvirinae, the human herpesviruses Herpes simplex virus-1 (HSV-1) and Herpes simplex virus-2 (HSV-2), use human epithelial cells to establish their lytic phase, and neuronal cells to establish a lysogenic (latent) phase.
N. Hristova, A.S. Galabov
openaire   +1 more source

Association between human genetic variants affecting the host NK cell response and the development of herpes simplex virus type 1 encephalitis

Journal of Medical Virology, Volume 95, Issue 5, May 2023., 2023
Abstract Herpes simplex virus encephalitis (HSE) is a rare complication of herpes simplex virus type 1 (HSV‐1) infection or reactivation. It is so far unclear why only few patients develop HSE. As natural killer (NK) cells provide an important defense against HSV‐1, we investigated whether there is an association between distinct human genetic variants
Marianne Graninger, Hannes Vietzen, Elisabeth Puchhammer‐Stöckl   +2 more
wiley   +1 more source

De Novo synthesis of VP16 coordinates the exit from HSV latency in vivo [PDF]

, 2009
The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this process remain unclear. The cascade
Preston, C.M., Sawtell, N.M., Thompson, R.L.   +2 more
core   +6 more sources