A broad wastewater screening and clinical data surveillance for virus-related diseases in the metropolitan Detroit area in Michigan [PDF]
Human GenomicsBackground Periodic bioinformatics-based screening of wastewater for assessing the diversity of potential human viral pathogens circulating in a given community may help to identify novel or potentially emerging infectious diseases.
Yabing Li +4 more
doaj +2 more sources
Development of rhesus macaque astrocyte cell lines supporting infection with a panel of viruses. [PDF]
PLoS ONENon-human primate (NHP)-based model systems are highly relevant for biomedical research. However, only few NHP cell lines are available and the generation of additional cell lines is an urgent need to help in the refinement and replacement of these ...
Stefanie Reiter +4 more
doaj +2 more sources
Bioinformatics-based screening tool identifies a wide variety of human and zoonotic viruses in Trujillo-Peru wastewater [PDF]
One HealthPeru was one of the most affected countries during the COVID-19 pandemic. Moreover, multiple other viral diseases (enteric, respiratory, bloodborne, and vector-borne) are endemic and rising.
Brijen Miyani +6 more
doaj +2 more sources
Exploring the Antiviral Potential of Tungsten Oxide Nanoparticles Against Herpes Simplex Virus Type 1: A Promising Alternative to Acyclovir. [PDF]
IET NanobiotechnolHerpes simplex virus type 1 (HSV‐1) is responsible for the majority of cold sores, herpetic keratitis‐induced blindness, profound skin lesions, and encephalitis that can be fatal. Currently, acyclovir and its derivatives are the first‐line therapy for the treatment of HSV‐1 infection.
Jwaziri AK +6 more
europepmc +2 more sources
A review of latency in the Alloherpesviridae family. [PDF]
J Fish DisAbstract The ability to impact the immune response of the host has been recognized as essential for the success of a virus during infection. A few groups of viruses can combine these immunomodulatory mechanisms with specific patterns of their own transcriptional and replication regulation to achieve persistence within the host long term.
Quijano Cardé EM, Soto E.
europepmc +2 more sources
Biotechnology & Biotechnological Equipment, 2023 Astragalus glycyphyllos L. is widely used in Bulgarian folk medicine. Extracts from this plant have antiproliferative, antitumor and immune stimulating effects in vitro and in vivo. The aim of this study was to examine the potential antiviral activity of
Aleksandar Shkondrov +8 more
doaj +1 more source
Phylogeographic analysis reveals an ancient East African origin of human herpes simplex virus 2 dispersal out-of-Africa [PDF]
Nature Communications, 2022 AbstractHuman herpes simplex virus 2 (HSV-2) is a ubiquitous, slowly evolving DNA virus. HSV-2 has two primary lineages, one found in West and Central Africa and the other found worldwide. Competing hypotheses have been proposed to explain how HSV-2 migrated out-of-Africa (i)HSV-2 followed human migration out-of-Africa 50-100 thousand years ago, or (ii)
Havens, Jennifer +5 more
openaire +6 more sources
Genus Simplexvirus: Life cycle
Acta Microbiologica Bulgarica, 2023 The two same-name members of the subfamily Alphaherpesvirinae, the human herpesviruses Herpes simplex virus-1 (HSV-1) and Herpes simplex virus-2 (HSV-2), use human epithelial cells to establish their lytic phase, and neuronal cells to establish a lysogenic (latent) phase.
N. Hristova, A.S. Galabov
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Pathogenesis, Diseases, Immune Response, and Chemotherapy of Genus Simplexvirus
Acta Microbiologica Bulgarica, 2023 Throughout evolution, members of the genus Simplexvirus have evolved a highly effective pathoge¬netic strategy based on biomolecular interactions with pathogen-sensitive biological species. This in turn leads to pathogen-associated recurrent diseases with a wide range of clinical manifestations, including her¬petic encephalitis (HSE), herpetic ...
N. Hristova, A.S. Galabov
openaire +1 more source
Intrinsically disordered regions are abundant in simplexvirus proteomes and display signatures of positive selection [PDF]
Virus Evolution, 2020 Abstract Whereas the majority of herpesviruses co-speciated with their mammalian hosts, human herpes simplex virus 2 (HSV-2, genus Simplexvirus) most likely originated from the cross-species transmission of chimpanzee herpesvirus 1 to an ancestor of modern humans. We exploited the peculiar evolutionary history of HSV-2 to investigate the
Mozzi A +5 more
openaire +4 more sources