Results 231 to 240 of about 1,429,075 (291)

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

The Behavior of Phenolic Compounds from Apples during Simulated Gastrointestinal Digestion with Focus on Chlorogenic Acid. [PDF]

Foods
Jakobek L, Pöc K, Valenteković M, Matić P.   +3 more
europepmc   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Protective Effects of Laminaria japonica Polysaccharide Composite Microcapsules on the Survival of Lactobacillus plantarum during Simulated Gastrointestinal Digestion and Heat Treatment. [PDF]

Mar Drugs
Guo H, Zhou Y, Xie Q, Chen H, Zhang M, Yu L, Yan G, Chen Y, Lin X, Zhang Y, Hong Z.   +10 more
europepmc   +1 more source

Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

British Journal of Pharmacology, EarlyView.
Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan, Rwdah Mohamed Alameri, Yasir S. Raouf, Damien Maurel, Naiem Ahmad Wani, Anatoliy Shmygol, Irfa Anwar, Heng B. See, Elizabeth K. M. Johnstone, Elodie Dupuis, Eric Trinquet, Kevin D. G. Pfleger, Emilia Oueis, Mohammed Akli Ayoub   +13 more
wiley   +1 more source

Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review

Clinical Genetics, EarlyView.
There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson, Marian Saab, Lily Thao Nguyen, Pooja Kochar, Olivia Meggetto, Jill Tinmouth, Meghan J. Walker   +6 more
wiley   +1 more source

Purification, characterization, simulated gastrointestinal digestion and gut microbiota fermentation of a Bifidobacterium-directed mannoglucan from Lilium brownii var. viridulum. [PDF]

Food Chem X
Bai G, Ye M, Yu L, Yang M, Wang Y, Chen S.   +5 more
europepmc   +1 more source

Regional and local divergence in welfare provision in England and Wales, 1776–1815

The Economic History Review, EarlyView.
Abstract This article uses the township‐level data on welfare expenditure and provision gathered by parish officers in England and Wales at three points between 1776 and 1815 to illuminate regional and local differences during the period. These data have been linked to geographic information system (GIS) mapping systems, facilitating the mapping of ...
John Broad
wiley   +1 more source

Method of meal delivery influences estimates of postprandial metabolism and alkaline tide in a benthic fish

Journal of Fish Biology, EarlyView.
Abstract Intragastric gavage is widely used in studies of digestive physiology to deliver standardised meals, yet it remains unclear whether it elicits postprandial metabolic and acid–base responses comparable to voluntary feeding. Here, we tested whether the method of meal delivery affects the magnitude and timing of the postprandial rise in metabolic
Junlin Chen, Barrett W. Wolfe, Harriet R. Goodrich   +2 more
wiley   +1 more source

Multi-layer encapsulation of pumpkin (Cucurbita maxima L.) seed protein hydrolysate and investigating its release and antioxidant activity in simulated gastrointestinal digestion. [PDF]

Heliyon
Nooshi Manjili Z, Sadeghi Mahoonak A, Ghorbani M, Shahiri Tabarestani H.   +3 more
europepmc   +1 more source