Results 31 to 40 of about 2,483 (141)

Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection

Cell Reports, 2021
Summary: New World hantaviruses (NWHs) are endemic in North and South America and cause hantavirus cardiopulmonary syndrome (HCPS), with a case fatality rate of up to 40%. Knowledge of the natural humoral immune response to NWH infection is limited. Here,
Taylor B. Engdahl, Natalia A. Kuzmina, Adam J. Ronk, Chad E. Mire, Matthew A. Hyde, Nurgun Kose, Matthew D. Josleyn, Rachel E. Sutton, Apoorva Mehta, Rachael M. Wolters, Nicole M. Lloyd, Francisca R. Valdivieso, Thomas G. Ksiazek, Jay W. Hooper, Alexander Bukreyev, James E. Crowe, Jr.   +15 more
doaj   +1 more source

Sin Nombre Virus Pathogenesis in Peromyscus maniculatus [PDF]

Journal of Virology, 1999
ABSTRACT Sin Nombre virus (SNV), a member of the Hantavirus genus, causes acute viral pneumonia in humans and is thought to persistently infect mice. The deer mouse, Peromyscus maniculatus , has been identified as the primary reservoir host for SNV. To understand SNV infection of
D, Netski, B H, Thran, S C, St Jeor
openaire   +2 more sources

Complete genetic characterization and analysis of isolation of Sin Nombre virus [PDF]

Journal of Virology, 1995
This study reports completion of the genetic characterization of the entire genome of Sin Nombre (SN) virus (NMH10) detected in autopsy tissues from a patient who died of hantavirus pulmonary syndrome (HPS). The large (L) genome segment was found to be 6,562 nucleotides in length and encoded a putative L polymerase that was 2,153 amino acids in length.
V E, Chizhikov, C F, Spiropoulou, S P, Morzunov, M C, Monroe, C J, Peters, S T, Nichol   +5 more
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Hantavirus and Arenavirus Antibodies in Persons with Occupational Rodent Exposure, North America

Emerging Infectious Diseases, 2007
Rodents are the principal hosts of Sin Nombre virus, 4 other hantaviruses known to cause hantavirus pulmonary syndrome in North America, and the 3 North American arenaviruses.
Charles F. Fulhorst, Mary Louise Milazzo, Lori R. Armstrong, James E. Childs, Pierre E. Rollin, Rima Khabbaz, C.J. Peters, Thomas G. Ksiazek   +7 more
doaj   +1 more source

Sin Nombre Virus mRNA Synthesis

Virology, 1996
Sin Nombre (SN) virus is the major etiologic agent of hantavirus pulmonary syndrome, a severe respiratory disease with high mortality. Like other hantaviruses, SN virus causes an inapparent chronic infection of the natural rodent reservoir and tends to grow slowly and produce little cytopathic effect even in highly susceptible Vero E6 tissue culture ...
Hutchinson, Karen L., Peters, Clarence J., Nichol, Stuart T.   +2 more
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Temporal Analysis of Andes Virus and Sin Nombre Virus Infections of Syrian Hamsters [PDF]

Journal of Virology, 2007
ABSTRACTAndes virus (ANDV) and Sin Nombre virus (SNV) are rodent-borne hantaviruses that cause a highly lethal hemorrhagic fever in humans known as hantavirus pulmonary syndrome (HPS). There are no vaccines or specific drugs to prevent or treat HPS, and the pathogenesis is not understood.
Victoria, Wahl-Jensen, Jennifer, Chapman, Ludmila, Asher, Robert, Fisher, Michael, Zimmerman, Tom, Larsen, Jay W, Hooper   +6 more
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Biodefense Implications of New-World Hantaviruses

Frontiers in Bioengineering and Biotechnology, 2020
Hantaviruses, part of the Bunyaviridae family, are a genus of negative-sense, single-stranded RNA viruses that cause two major diseases: New-World Hantavirus Cardiopulmonary Syndrome and Old-World Hemorrhagic Fever with Renal Syndrome.
Michael Hilary D’Souza, Trushar R. Patel, Trushar R. Patel, Trushar R. Patel   +3 more
doaj   +1 more source

Sin nombre virus glycoprotein trafficking

Virology, 2003
Sin Nombre virus (SNV) is a major representative of the New World hantaviruses and the most common cause of hantavirus pulmonary syndrome (HPS) with high mortality in North America. Unlike other members of the family Bunyaviridae which mature in the Golgi complex, New World hantaviruses have been previously reported to mature at the cell surface.
Spiropoulou, C.F, Goldsmith, C.S, Shoemaker, T.R, Peters, C.J, Compans, R.W   +4 more
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The Coiled-coil Domain Structure of the Sin Nombre Virus Nucleocapsid Protein [PDF]

Journal of Molecular Biology, 2007
Hantaviruses can cause hemorrhagic fever with a renal syndrome and hantavirus pulmonary syndrome when transmitted to humans. The nucleocapsid protein of hantaviruses encapsidates viral genomic RNA and associates with transcription and replication complexes.
Sergei P, Boudko, Richard J, Kuhn, Michael G, Rossmann   +2 more
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Naturally Occurring Sin Nombre Virus Genetic Reassortants

Virology, 1995
Genetic reassortment has been shown to play an important role in the evolution of several segmented RNA viruses and in the epidemiology of associated diseases. Sin Nombre (SN) virus is the cause of hantavirus pulmonary syndrome throughout the western United States.
HENDERSON, WINNIE W., MONROE, MARTHA C., ST. JEOR, STEPHEN C., THAYER, WESLEY P., ROWE, JOAN E., PETERS, C.J., NICHOL, STUART T.   +6 more
openaire   +2 more sources