Results 61 to 70 of about 22,347 (256)

Clinical signs, clinical pathology and outcomes in horses infected naturally with equine encephalosis virus

Equine Veterinary Journal, EarlyView.
Abstract Background Equine encephalosis (EE) is caused by an Orbivirus from the family Sedoreoviridae and is thus similar to African horse sickness (AHS) and Bluetongue viruses (BTV). These viruses are transmitted by Culicoides midges. Equine encephalosis can infect horses, donkeys and zebras sub‐clinically while only horses develop clinical disease ...
Graeme Piketh, Adrienne Viljoen, Christina Eberhardt   +2 more
wiley   +1 more source

Use of a lambda gt11 expression library to localize a neutralizing antibody-binding site in glycoprotein E2 of Sindbis virus [PDF]

, 1991
The Sindbis virus envelope contains two species of integral membrane glycoproteins, E1 and E2. These proteins form heterodimers, and three dimeric units assemble to form spikes incorporated into the viral surface which play an important role in the ...
Strauss, James H., Wang, Kang-Sheng
core   +1 more source

Mathematical Modeling of the Role of Cytokines in Sindbis Virus Treatment of Glioblastoma

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Oncolytic viruses, specifically Sindbis virus (SINV), combined with cytokines show promising results in slowing glioma progression, but a quantitative understanding of their effects remains limited. In this study, we use an ordinary differential equation (ODE) model to examine the effect of adding cytokines to oncolytic SINV therapy.
Shriya Makam, Hana M. Dobrovolny
wiley   +1 more source

Mapping of RNA- temperature-sensitive mutants of Sindbis virus: assignment of complementation groups A, B, and G to nonstructural proteins [PDF]

, 1989
Four complementation groups of temperature-sensitive (ts) mutants of Sindbis virus that fail to make RNA at the nonpermissive temperature are known, and we have previously shown that group F mutants have defects in nsP4.
Hahn, Young S., Strauss, Ellen G., Strauss, James H.   +2 more
core   +1 more source

Molecular Screening of Black Flies (Diptera: Simuliidae) for Vector‐Borne Zoonotic Pathogens, South Moravia, Czech Republic

Zoonoses and Public Health, Volume 73, Issue 1, Page 95-106, February 2026.
ABSTRACT Introduction Black flies (Simuliidae) are globally distributed blood‐feeding arthropods and vectors of viral, bacterial, and parasitic pathogens to many animal species, including humans. We investigated the occurrence of selected vector‐borne pathogens in black flies in South Moravia, Czech Republic, and evaluated their possible role in the ...
Silvie Šikutová, Kristína Mravcová, Jan Mendel, Oldřich Šebesta, Bohumil Sak, Nikola Holubová, Martin Kváč, Clifton McKee, Peter H. Adler, D. Otranto, Ivo Rudolf   +10 more
wiley   +1 more source

Efficiency of Transduction by Recombinant Sindbis Replicon Virus Varies Among Cell Lines, Including Mosquito Cells and Rat Sensory Neurons

BioTechniques, 1996
Recombinant alphaviruses have been used as vehicles for delivery and expression of heterologous genes in mammalian, avian and insect cell lines. We have used a Sindbis replicon virus (Sinreplac) able to express the E.
J. Corsini, D.L. Traul, C.L. Wilcox, P. Gaines, J.O. Carlson   +4 more
doaj   +1 more source

Sindbis virus ts103 has a mutation in glycoprotein E2 that leads to defective assembly of virions [PDF]

, 1989
Sindbis virus mutant ts103 is aberrant in the assembly of virus particles. During virus budding, proper nucleocapsid-glycoprotein interactions fail to occur such that particles containing many nucleocapsids are formed, and the final yield of virus is low.
Hahn, Chang S., Lenches, Edith M., Rice, Charles M., Strauss, Ellen G., Strauss, James H.   +4 more
core  

The selectivity and specificity of autophagy in drosophila [PDF]

, 2012
Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a ...
Chou, Clark, Contamine, Deng, Dezelee, Finley, Fouillet, Goto, Kadandale, McPhee, Midorikawa, Nezis, Nisoli, Novak, Orvedahl, Pankiv, Park, Rello-Varona, Schweers, Shoji, Simonsen, Tian, Webb, Wild, Wyers, Yu, Yu, Ziviani   +27 more
core   +2 more sources

RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors

Advanced Science, Volume 13, Issue 4, 19 January 2026.
RNA interference (RNAi) is vital for eukaryotes to defend against virus infection. The C3PO complex takes part in RNAi but its role in regulating viral infection remains unclear. This work finds that insect C3PO facilitates arbovirus replication by degrading precursors of miRNAs, especially miR‐971‐3p.
Yan Xiao, Tianyu Guan, Qianfeng Xia, Chen Chen, Qian Wang, Lan Luo, Hong Lu, Feng Cui   +7 more
wiley   +1 more source

Cell-specific targeting of lentiviral vectors mediated by fusion proteins derived from Sindbis virus, vesicular stomatitis virus, or avian sarcoma/leukosis virus

Retrovirology, 2010
Background The ability to efficiently and selectively target gene delivery vectors to specific cell types in vitro and in vivo remains one of the formidable challenges in gene therapy.
Marino Michael P, Bialkowska Agnieszka, Kutner Robert H, Zhang Xian-Yang, Klimstra William B, Reiser Jakob   +5 more
doaj   +1 more source