Results 71 to 80 of about 22,215 (261)
Advances and Strategies in Enhancing mRNA Cancer Vaccines
Advanced Materials, Volume 37, Issue 42, October 23, 2025.Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang +4 more
wiley +1 more source
Journal of Insect Science, 2001 Sindbis virus expression vectors have been used successfully to express and silence genes of interest in vivo in several mosquito species, including Aedes aegypti, Ae. albopictus, Ae. triseriatus, Culex pipiens, Armigeres subalbatus and Anopheles gambiae.
L.L. Cheng +7 more
doaj
Viruses, 2019 Sindbis virus (SINV) is a mosquito-borne alphavirus circulating globally. SINV outbreaks have been mainly reported in North-European countries. In Israel, SINV was detected in 6.3% of mosquito pools; however, SINV infection in humans has rarely been ...
Ravit Koren +6 more
doaj +1 more source
Site-directed mutagenesis of the proposed catalytic amino acids of the Sindbis virus capsid protein autoprotease [PDF]
, 1990 The structural proteins of Sindbis virus are translated as a polyprotein precursor that is cleaved upon translation. The capsid protein is postulated to be a serine protease that releases itself from the N terminus of the nascent polyprotein by ...
Hahn, Chang S., Strauss, James H.
core
Why enveloped viruses need cores -- the contribution of a nucleocapsid core to viral budding
, 2017 During the alphavirus lifecycle, a nucleocapsid core buds through the cell membrane to acquire an outer envelope of lipid membrane and viral glycoproteins. However, the presence of a nucleocapsid core is not required for assembly of infectious particles.
Hagan, Michael F. +2 more
core +1 more source
Targeting lentiviral vectors to antigen-specific immunoglobulins [PDF]
, 2008 Gene transfer into B cells by lentivectors can provide an alternative approach to managing B lymphocyte malignancies and autoreactive B cell-mediated autoimmune diseases.
Black M.E. +17 more
core +2 more sources
Advanced Science, Volume 12, Issue 38, October 13, 2025.Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil +12 more
wiley +1 more source
Membrane-Mediated Alterations of Intracellular Na+ and K+ in Lytic-Virus-Infected and Retrovirus-Transformed Cells [PDF]
Infection of chick-embryo fibroblasts and other ceils by certain animal viruses results in alterations in the intracellular concentrations of Na + and K +.
Bose, Henry R. +2 more
core +1 more source
Imaging high-resolution structure of GFP-expressing neurons in neocortex in vivo [PDF]
, 2000 To detect subtle changes in neuronal morphology in response to changes in experience, one must image neurons at high resolution in vivo over time scales of minutes to days.
Burbach, B. +5 more
core +1 more source
Interaction of Sindbis virus glycoproteins during morphogenesis [PDF]
Journal of Virology, 1977 In cells infected with the Sindbis temperature-sensitive mutants ts-23 and ts-10 (complementation group D), which contain a defect in the envelope glycoprotein E1, the precursor polypeptide PE2 is not cleaved to the envelope glycoprotein E2 at the nonpermissive temperature.
K J, Jones +5 more
openaire +2 more sources