Targeting lentiviral vectors to antigen-specific immunoglobulins [PDF]
Gene transfer into B cells by lentivectors can provide an alternative approach to managing B lymphocyte malignancies and autoreactive B cell-mediated autoimmune diseases.
Black M.E. +17 more
core +2 more sources
Pepino Mosaic Virus: A Globally Important Tomato Pathogen and a Rising Model in Molecular Virology
Pepino mosaic virus (PepMV) is a globally important tomato pathogen causing fruit quality losses. It comprises multiple genetic types and spreads via seed and mechanical contact. Lacking resistant cultivars, management relies on cross‐protection. PepMV–tomato interactions provide a valuable model for studying virus–plant molecular mechanisms and ...
Jesús R. Úbeda +3 more
wiley +1 more source
Interaction of Sindbis virus glycoproteins during morphogenesis [PDF]
In cells infected with the Sindbis temperature-sensitive mutants ts-23 and ts-10 (complementation group D), which contain a defect in the envelope glycoprotein E1, the precursor polypeptide PE2 is not cleaved to the envelope glycoprotein E2 at the nonpermissive temperature.
K J, Jones +5 more
openaire +2 more sources
Why enveloped viruses need cores -- the contribution of a nucleocapsid core to viral budding
During the alphavirus lifecycle, a nucleocapsid core buds through the cell membrane to acquire an outer envelope of lipid membrane and viral glycoproteins. However, the presence of a nucleocapsid core is not required for assembly of infectious particles.
Hagan, Michael F. +2 more
core +1 more source
Imaging high-resolution structure of GFP-expressing neurons in neocortex in vivo [PDF]
To detect subtle changes in neuronal morphology in response to changes in experience, one must image neurons at high resolution in vivo over time scales of minutes to days.
Burbach, B. +5 more
core +1 more source
Mosquitoborne Viruses, Czech Republic, 2002
Specimens from residents (n = 497) of an area affected by the 2002 flood were examined serologically for mosquitoborne viruses. Antibodies were detected against Tahyna (16%), Sindbis (1%), and Batai (0.2%) viruses, but not West Nile virus. An examination
Zdenek Hubálek +7 more
doaj +1 more source
Phospholipid Synthesis in Sindbis Virus-Infected Cells [PDF]
We investigated the metabolic requirements for the decrease in phospholipid synthesis previously observed by Pfefferkorn and Hunter in primary cultures of chick embryo fibroblasts infected with Sindbis virus. The incorporation of 32 PO 4 into all classes of phospholipids was found to decline ...
M R, Waite, E R, Pfefferkorn
openaire +2 more sources
Sindbis virus proteins nsP1 and nsP2 contain homology to nonstructural proteins from several RNA plant viruses [PDF]
Although the genetic organization of tobacco mosaic virus (TMV) differs considerably from that of the tripartite viruses (alfalfa mosaic virus [AlMV] and brome mosaic virus [BMV]), all of these RNA plant viruses share three domains of homology among ...
Ahlquist, Paul +5 more
core +1 more source
Mutations in the E2 glycoprotein and the 3\u27 untranslated region enhance chikungunya virus virulence in mice [PDF]
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes debilitating musculoskeletal pain and inflammation and can persist for months to years after acute infection.
Carpentier, Kathryn S +8 more
core +3 more sources
A bioelectronic sensor integrating 2D cell membranes with organic microelectrode arrays enables detection of SARS‐CoV‐2 fusion pathways. Natively‐expressed viral receptors promote monitoring of viral entry and screening of antibody‐based inhibitors.
Zixuan Lu +17 more
wiley +1 more source

