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The trajectory of microbial single-cell sequencing
Nature Methods, 2017Over the past decade, it has become nearly routine to sequence genomes of individual microbial cells directly isolated from environmental samples ranging from deep-sea hydrothermal vents to insect guts, providing a powerful complement to shotgun metagenomics in microbial community studies. In this review, we address the technical aspects and challenges
Tanja Woyke +2 more
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Single-Cell Sequencing in Precision Medicine
2019The application of next-generation sequencing in cancer genomics allowed for a better understanding of the genetics and pathogenesis of cancer. Single-cell genomics is a relatively new field that has enhanced our current knowledge of the genetic diversity of cells involved in the complex biological systems of cancer.
Julia E, Wiedmeier +4 more
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Preparation of single cells from tumors for single-cell RNA sequencing
2020Intratumoral heterogeneity of cancer cells and tumor-infiltrating immune cells is increasingly being viewed as a key factor driving tumor progression and response to therapy. Over the past several years, technological advances have created powerful tools to analyze the tumor microenvironment on a single-cell level, including mass cytometry and single ...
Yonina, Bykov +2 more
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Single-Cell Sequencing of Microorganisms
2015Only a small fraction (estimated to be less than 1 %) of microbial species on Earth can be cultivated in the laboratory; thus, the standard microbial research methods based on pure culture isolation and observation can provide only very limited information about an environmental microbial community.
Ying Chen, Fengping Wang
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Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing
Cell, 2020Ashley Maynard +2 more
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