Results 201 to 210 of about 502,506 (259)

Single-Chain Variable Fragment-Based Dot Blot, Single, and Multiple Assays for Rapid SARS-CoV-2 Diagnostics. [PDF]

J AOAC Int
Çam Derin D, Gültekin E, Taşkın Iİ, Dündar M, Otlu B.   +4 more
europepmc   +1 more source

scFv-based biologics in diabetes: from therapeutic potential to clinical prospects. [PDF]

Front Immunol
Ge S, Wang L, Huang Y, Guo H, Wei F, Li P, Li S, Liu Q, Xu J, Xiao Y, Piress Dias AC, Ji L.   +11 more
europepmc   +1 more source

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Medical Applications of Single-Chain Antibodies

International Reviews of Immunology, 1993
A single-chain antibody or single-chain Fv (sFv) incorporates the complete antibody binding site in a single polypeptide chain of minimal size, with an approximate molecular weight of 26,000. In antibodies, the antigen combining site is part of the Fv region, which is composed of the VH and VL variable domains on separate heavy and light chains ...
M S Tai, J S Huston, James S Huston
exaly   +3 more sources

Recombinant single chain antibodies in bioelectrochemical sensors

Talanta, 2001
Recombinant antibodies provide an emerging strategy in the development of new immunosensors. In particular, single chain antibodies (scFvs) can be isolated and expressed in bacterial systems that also allow their in vitro manipulation at the gene level.
Itai Benhar, J Rishpon
exaly   +3 more sources

Preparing recombinant single chain antibodies

Chemical Engineering Science, 2008
A review of current processing practices in preparation of recombinant single chain antibody fragments is presented. Single chain antibody fragments which are superior to their Fab and IgG counterparts due to their higher affinity for target antigens while imposing minimal antigenicity in recipient hosts, have sparked breakthroughs in immunology and ...
Wei Ning Chen
exaly   +2 more sources

Expression of single-chain antibodies in transgenic plants

Vaccine, 2005
There is an ever-growing interest in plant molecular farming as a system for producing valuable recombinant pharmaceutical molecules, such as single-chain variable fragments, on an industrial/agricultural scale and it appears that it is going to become a reality.
Patrizio Giacomini, Patrizia Galeffi
exaly   +3 more sources

Single chain antibody variable regions

Trends in Biotechnology, 1991
The use of antibodies or antibody fragments for targeting tumors (either for tumor imaging or as carriers for drugs or toxins), has encountered problems of clearance, and non-specific or inefficient binding in clinical trials. A novel approach, linking two antibody variable fragments (Fvs), with a short peptide to generate a continuous polypeptide ...
R E, Bird, B W, Walker
openaire   +2 more sources

Single‐Chain Antibodies in Pancreatic Cancer

Annals of the New York Academy of Sciences, 1999
Abstract: Pancreatic cancer is a therapeutic challenge for surgical and medical oncology. Development of specific molecular tracers for the diagnosis and treatment of this lethal cancer has been one of our major goals. Monoclonal antibodies (MAbs) have been successfully used as selective carriers for delivering radionuclides, toxins or cytotoxic drugs
D, Colcher, G, Pavlinkova, G, Beresford, B J, Booth, S K, Batra   +4 more
openaire   +2 more sources

Phage Display of Single‐Chain Antibody Constructs

Current Protocols in Immunology, 2002
AbstractPhage display is based on expressing recombinant proteins fused to a phage coat protein. The genetic information encoding for the displayed molecule is physically linked to its product via the displaying particle. With phage display, tailor‐made proteins (fused peptides, antibodies, enzymes, DNA‐binding proteins) may be synthesized and selected
Itai, Benhar, Yoram, Reiter
openaire   +2 more sources