Results 151 to 160 of about 606,803 (250)

Strain‐Programmable Luminescent Adhesive Patch With Tartrazine‐Mediated Optical Skin Clearing for Photochemical Tissue Bonding

Advanced Functional Materials, EarlyView.
We propose a suture‐complementary approach that integrates optical skin clearing with a strain‐programmable luminescent adhesive patch. Hyaluronic acid promotes transdermal delivery of tartrazine to improve optical clearing and stabilizes its interaction with a photosensitizer. Optical clearing increases the penetration depth of visible light into skin,
Seong‐Jong Kim, Kyungjoo Jo, Kwanghyeon Park, Jun Hee Kim, Jong Hyeong Cho, Inhoo Choi, Sei Kwang Hahn   +6 more
wiley   +1 more source

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base. [PDF]

Nat Commun
De Cae S, Van Molle I, van Schie L, Shoemaker SR, Deckers J, Debeuf N, Lameire S, Nerinckx W, Roose K, Fijalkowska D, Devos S, De Smet AS, Marchan JCZ, Venneman T, Sedeyn K, Mujanovic L, Ballegeer M, Vanheerswynghels M, De Wolf C, Demol H, Zuallaert J, Vanhaverbeke P, Ghassabeh GH, Lonigro C, Bockstal V, Rinaldi M, Abdelnabi R, Neyts J, Marqusee S, Lambrecht BN, Callewaert N, Remaut H, Saelens X, Schepens B.   +33 more
europepmc   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies. [PDF]

Front Immunol
Pudewell S, Heuser J, Dorogobed I, Lipinski B, Tran THH, Metzenmacher P, Kunze R, Geyer F, Zielonka S, Floss DM, Kolmar H, Moll JM, Scheller J.   +12 more
europepmc   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Editorial: Single-domain antibodies-biology, engineering and emerging applications, volume II. [PDF]

Front Immunol
Henry KA, Hussack G, Gettemans J, Brooks CL.   +3 more
europepmc   +1 more source

Magnesium‐Based Transient Bioelectronics, Bio‐Optics and Bio‐Scaffolds

Advanced Functional Materials, EarlyView.
This paper reviews the state of the art and recent advances in magnesium‐based thin‐film, foils, and scaffolds for applications in transient bio‐optics, bioelectronics and tissue engineering. The design principles, fabrication methods, material properties, and integration strategies are discussed in detail.
Massimo Mariello, Yves Leterrier
wiley   +1 more source

Corrigendum: Genetic Removal of the CH1 Exon Enables the Production of Heavy Chain-Only IgG in Mice

Frontiers in Immunology, 2019
Tianyi Zhang, Xueqian Cheng, Di Yu, Fuyu Lin, Ning Hou, Xuan Cheng, Shanshan Hao, Jingjing Wei, Li Ma, Yanbin Fu, Yonghe Ma, Liming Ren, Haitang Han, Shuyang Yu, Xiao Yang, Yaofeng Zhao   +15 more
doaj   +1 more source

Generative Deep Learning Design of Single-Domain Antibodies Against Venezuelan Equine Encephalitis Virus. [PDF]

Antibodies (Basel)
Liu JL, Bayacal GC, Alvarez JAE, Shriver-Lake LC, Goldman ER, Dean SN.   +5 more
europepmc   +1 more source