Immunogenicity and humanization of single‐domain antibodies [PDF]
The FEBS Journal, 2021 Single‐domain antibodies (sdAbs), the autonomous variable domains of camelid and shark heavy‐chain antibodies, have many desirable properties as components of biologic drugs.
M. Rossotti +3 more
semanticscholar +3 more sources
Single Domain Antibodies as New Biomarker Detectors [PDF]
Diagnostics, 2017 Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for ...
Chiuan Herng Leow +5 more
doaj +4 more sources
Camelid Single-Domain Antibodies: Historical Perspective and Future Outlook
Frontiers in Immunology, 2017 Tremendous effort has been expended over the past two and a half decades to understand many aspects of camelid heavy chain antibodies, from their biology, evolution, and immunogenetics to their potential applications in various fields of research and ...
Mehdi Arbabi-Ghahroudi +1 more
doaj +2 more sources
Inhibition of tau neuronal internalization using anti-tau single domain antibodies [PDF]
Nature CommunicationsIn Alzheimer’s disease, tau pathology spreads across brain regions as the disease progresses. Intracellular tau can be released and taken up by nearby neurons.
Clément Danis +12 more
doaj +2 more sources
Cross-Reactive and Lineage-Specific Single Domain Antibodies against Influenza B Hemagglutinin
Antibodies, 2019 Influenza B virus (IBV) circulates in the human population and causes considerable disease burden worldwide, each year. Current IBV vaccines can struggle to mount an effective cross-reactive immune response, as strains become mismatched, due to constant ...
Walter Ramage +8 more
doaj +2 more sources
Single-Domain Antibodies As Therapeutics against Human Viral Diseases
Frontiers in Immunology, 2017 In full-size formats, monoclonal antibodies have been highly successful as therapeutics against cancer and immune diseases. However, their large size leads to inaccessibility of some epitopes and relatively high production costs.
Yanling Wu, Shibo Jiang, Tianlei Ying
doaj +2 more sources
Ricin Detection Using Phage Displayed Single Domain Antibodies [PDF]
Sensors, 2009 Phage-displayed single domain antibodies (sdAb) were compared to monomeric solubly expressed sdAb and llama polyclonal antibodies for the detection of ricin. SdAb are comprised of the variable domain derived from camelid heavy chain only antibodies (HcAb)
Ellen R. Goldman +5 more
doaj +3 more sources
Generic semi-automated radiofluorination strategy for single domain antibodies: [18F]FB-labelled single domain antibodies for PET imaging of fibroblast activation protein-α or folate receptor-α overexpression in cancer [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Radiofluorination of single domain antibodies (sdAbs) via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) has shown to be a promising strategy in the development of sdAb-based PET tracers. While automation of the prosthetic group (PG) [18F]SFB
Herlinde Dierick +11 more
doaj +2 more sources
Single domain antibodies from camelids in the treatment of microbial infections [PDF]
Frontiers in ImmunologyInfectious diseases continue to pose significant global health challenges. In addition to the enduring burdens of ailments like malaria and HIV, the emergence of nosocomial outbreaks driven by antibiotic-resistant pathogens underscores the ongoing ...
Henri De Greve +3 more
doaj +2 more sources
Enhancing Stability of Camelid and Shark Single Domain Antibodies: An Overview
Frontiers in Immunology, 2017 Single domain antibodies (sdAbs) are gaining a reputation as superior recognition elements as they combine the advantages of the specificity and affinity found in conventional antibodies with high stability and solubility.
Ellen R. Goldman +3 more
doaj +2 more sources