Results 21 to 30 of about 865,522 (266)

Selection of Single-Domain Antibodies towards Western Equine Encephalitis Virus

Antibodies, 2018
In this work, we describe the selection and characterization of single-domain antibodies (sdAb) towards the E2/E3E2 envelope protein of the Western equine encephalitis virus (WEEV).
Jinny L. Liu, Lisa C. Shriver-Lake, Dan Zabetakis, Ellen R. Goldman, George P. Anderson   +4 more
doaj   +2 more sources

NKp46‐specific single domain antibodies enable facile engineering of various potent NK cell engager formats

Protein Science, 2023
Herein, we describe the generation of potent NK cell engagers (NKCEs) based on single domain antibodies (sdAbs) specific for NKp46 harboring the humanized Fab version of Cetuximab for tumor targeting.
Britta Lipinski, Paul Arras, Lukas Pekar, Daniel Klewinghaus, Ammelie Svea Boje, Simon Krah, Jasmin Zimmermann, Katja Klausz, M. Peipp, Vanessa Siegmund, Andreas Evers, Stefan Zielonka   +11 more
semanticscholar   +1 more source

Physicochemical differences between camelid single-domain antibodies and mammalian antibodies. [PDF]

Turk J Biol, 2023
In recent years, single-domain antibodies, also known as nanobodies, have emerged as an alternative to full immunoglobulin Gs (IgGs), due to their various advantages, including increased solubility, faster clearance, and cheaper production. Nanobodies are generally derived from the variable domain of the camelid heavy-chain-only immunoglobulin Gs ...
Eskier NE, Eskier D, Firuzan E, Uzunlar SK.   +3 more
europepmc   +3 more sources

Importance of Hypervariable Region 2 for Stability and Affinity of a Shark Single-Domain Antibody Specific for Ebola Virus Nucleoprotein. [PDF]

PLoS ONE, 2016
Single-domain antibodies derived from the unique New Antigen Receptor found in sharks have numerous potential applications, ranging from diagnostic reagents to therapeutics.
George P Anderson, Daniel D Teichler, Dan Zabetakis, Lisa C Shriver-Lake, Jinny L Liu, Stephen G Lonsdale, Sarah A Goodchild, Ellen R Goldman   +7 more
doaj   +1 more source

Camelid Single-Domain Antibodies: Promises and Challenges as Lifesaving Treatments

International Journal of Molecular Sciences, 2022
Since the discovery of camelid heavy-chain antibodies in 1993, there has been tremendous excitement for these antibody domains (VHHs/sdAbs/nanobodies) as research tools, diagnostics, and therapeutics.
M. Arbabi-Ghahroudi
semanticscholar   +1 more source

Integrating Single Domain Antibodies into Field-Deployable Rapid Assays

Antibodies, 2022
Single domain antibodies (sdAb) are the recombinant variable heavy domains derived from camelid heavy-chain antibodies. While they have binding affinities equivalent to conventional antibodies, sdAb are only one-tenth the size and possess numerous ...
George P. Anderson, Lisa C. Shriver-Lake, Jinny L. Liu, Ellen R. Goldman   +3 more
doaj   +1 more source

Research progress on unique paratope structure, antigen binding modes, and systematic mutagenesis strategies of single-domain antibodies

Frontiers in Immunology, 2022
Single-domain antibodies (sdAbs) showed the incredible advantages of small molecular weight, excellent affinity, specificity, and stability compared with traditional IgG antibodies, so their potential in binding hidden antigen epitopes and hazard ...
C. Liu, Honghuang Lin, Limin Cao, Kaiqiang Wang, Jianxin Sui   +4 more
semanticscholar   +1 more source

Development and evaluation of single domain antibodies for vaccinia and the L1 antigen. [PDF]

PLoS ONE, 2014
There is ongoing interest to develop high affinity, thermal stable recognition elements to replace conventional antibodies in biothreat detection assays. As part of this effort, single domain antibodies that target vaccinia virus were developed.
Scott A Walper, Jinny L Liu, Daniel Zabetakis, George P Anderson, Ellen R Goldman   +4 more
doaj   +1 more source

Central Nervous System Delivery of Antibodies and Their Single-Domain Antibodies and Variable Fragment Derivatives with Focus on Intranasal Nose to Brain Administration

Antibodies, 2021
IgG antibodies are some of the most important biopharmaceutical molecules with a high market volume. In spite of the fact that clinical therapies with antibodies are broadly utilized in oncology, immunology and hematology, their delivery strategies and ...
A. Soleimanizadeh, Heiko Dinter, K. Schindowski   +2 more
semanticscholar   +1 more source

Robust anti-SARS-CoV2 single domain antibodies cross neutralize multiple viruses

iScience, 2022
Summary: We report robust SARS-CoV2 neutralizing sdAbs targeting the viral peptides encompassing the polybasic cleavage site (CSP) and in the receptor binding domain (RBD) of the spike (S) protein.
Sudhakar Singh, Surbhi Dahiya, Yuviana J. Singh, Komal Beeton, Ayush Jain, Roman Sarkar, Abhishek Dubey, Azeez Tehseen, Sharvan Sehrawat   +8 more
doaj   +1 more source