Results 91 to 100 of about 8,018,858 (254)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
IEEE AccessThis paper studies Higher-Order Serial Differentiators (HOSDs) under bounded input perturbations and develops rigorous event-based convergence bounds for their estimation errors. The analysis is formulated in terms of quasi-exponential convergence (QEC),
Jang-Hyun Park, Sun-Pil Kim
doaj +1 more source
On Chip Characterization of Single Event Transient Pulse Widths
, 2005 It is now well known to the radiation effects community that single event effects caused by energetic particles, particularly single event transients, will be among the dominant reliability issues in advanced integrated circuits.
Narasimham, Balaji
core
Single event transient reliability analysis on a fault-tolerant RISC-V microprocessor design
The miniaturization of electronic devices and the improved operating speeds increase the likelihood of single event faults. Differently from Single Event Upset (SEU) faults, Single Event Transient (SET) faults generally affect combinational logic, making
Mastrandrea, Antonio +6 more
core +1 more source
Independent Single Event Upset Testing of the Microsemi RTG4: Preliminary Data [PDF]
, 2016 This is a NASA Electronics Parts and Packaging (NEPP) independent investigation to determine the single event destructive and transient susceptibility of the Microsemi RTG4 device (DUT)
Seidleck, Christina +4 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Characterization of transient events during intermittent photic stimulation
NeuroImageAnalyzing single-trial neuroelectrophysiological data complements average processing pipelines aiming to better understand generation mechanisms of brain oscillations and transient events.
Hannes Oppermann +4 more
doaj +1 more source
Human motor cortical beta bursts relate to movement planning and response errors.
PLoS Biology, 2019 Motor cortical beta activity (13-30 Hz) is a hallmark signature of healthy and pathological movement, but its behavioural relevance remains unclear.
Simon Little +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source