Results 211 to 220 of about 315,481 (343)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Incretin polyagonists as an alternative to bariatric surgery to manage obesity. [PDF]

World J Gastrointest Pathophysiol
Manoj RJ, Fernandez CJ, Nair S, Pappachan JM.   +3 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Real-world safety profile of T-cell engagers: evidence from multi-database analysis with CAR-T comparisons. [PDF]

Front Immunol
Zhong J, Chen C, Xu Y, He Y, Luo J, Zhang C, Tan J, Xiong D.   +7 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Prognostic alternative splicing signatures in esophageal cancer reveal SF3A3 as a key oncogenic splicing factor. [PDF]

Transl Cancer Res
Mo J, Zou Y, Zhang J, Miao H, Chen D.
europepmc   +1 more source

Use of FRAM memories in spacecrafts [PDF]

, 2011
Sansoè C., Tranchero M.
core   +2 more sources

Comparison of neutron induced single event upsets in 14 nm FinFET and 65 nm planar static random access memory devices

, 2020
Zhangang Zhang, Zhi-Feng Lei, Teng Tong, Xiaohui Li, Songlin Wang, Tianjiao Liang, Kai Xi, Chao Peng, Yu-Juan He, Yun Huang, Yunfei En   +10 more
openalex   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Clinical Impact of Angiographic Complications Occurring During Percutaneous Coronary Interventions. [PDF]

Catheter Cardiovasc Interv
Bianchini E, Lunardi M, Casamassima F, Bianchini F, Basile M, Romagnoli E, Aurigemma C, Paraggio L, Fracassi F, Montone RA, Buffon A, Cappannoli L, Ierardi C, Sanna T, Leone AM, Trani C, Burzotta F.   +16 more
europepmc   +1 more source