Results 101 to 110 of about 852,815 (296)

A Novel Single Domain Antibody Targeting FliC Flagellin of Salmonella enterica for Effective Inhibition of Host Cell Invasion

Frontiers in Microbiology, 2019
The enteric pathogen, Salmonella enterica is a major cause of human gastroenteritis globally and with increasing bacterial resistance to antibiotics, alternative solutions are urgently needed.
Jennifer Huen, Jennifer Huen, Jennifer Huen, Zhun Yan, Jeremy Iwashkiw, Shraddha Dubey, Maria C. Gimenez, Maria C. Gimenez, Maria E. Ortiz, Maria E. Ortiz, Saumil V. Patel, Michael D. Jones, Ali Riazi, Mauricio Terebiznik, Mauricio Terebiznik, Saeid Babaei, Dea Shahinas   +16 more
doaj   +1 more source

A Comparative Study of the Structural Dynamics of Four Terminal Uridylyl Transferases. [PDF]

, 2017
African trypanosomiasis occurs in 36 countries in sub-Saharan Africa with 10,000 reported cases annually. No definitive remedy is currently available and if left untreated, the disease becomes fatal.
Amaro, Rommie E, Cheng, Kevin J, Demir, Özlem   +2 more
core   +1 more source

Binding of HIV-1 gp41-Directed Neutralizing and Non-Neutralizing Fragment Antibody Binding Domain (Fab) and Single Chain Variable Fragment (ScFv) Antibodies to the Ectodomain of gp41 in the Pre-Hairpin and Six-Helix Bundle Conformations

PLoS ONE, 2014
We previously reported a series of antibodies, in fragment antigen binding domain (Fab) formats, selected from a human non-immune phage library, directed against the internal trimeric coiled-coil of the N-heptad repeat (N-HR) of HIV-1 gp41. Broadly neutralizing antibodies from that series bind to both the fully exposed N-HR trimer, representing the pre-
John M Louis, Annie Aniana, Katheryn Lohith, Jane M Sayer, Julien Roche, Carole A Bewley, G Marius Clore   +6 more
openaire   +4 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Increasing evidence of mechanical force as a functional regulator in smooth muscle myosin light chain kinase

eLife, 2017
Mechanosensitive proteins are key players in cytoskeletal remodeling, muscle contraction, cell migration and differentiation processes. Smooth muscle myosin light chain kinase (smMLCK) is a member of a diverse group of serine/threonine kinases that ...
Fabian Baumann, Magnus Sebastian Bauer, Martin Rees, Alexander Alexandrovich, Mathias Gautel, Diana Angela Pippig, Hermann Eduard Gaub   +6 more
doaj   +1 more source

Lectin-like bacteriocins from pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor [PDF]

, 2014
Lectin-like bacteriocins consist of tandem monocot mannose-binding domains and display a genus-specific killing activity. Here we show that pyocin L1, a novel member of this family from Pseudomonas aeruginosa, targets susceptible strains of this species ...
A Hviid, A Molinaro, AC Graham, AD Vinion-Dubiel, AHA Parret, AHA Parret, AJ McCoy, Aleksander W. Roszak, AM Abdel-Mawgoud, AW Schuttelkopf, Brian Smith, C Kleanthous, C Manichanh, CL Brown, CL Ng, D Franke, D Walker, Daniel Walker, DI Svergun, E Cascales, E Kurimoto, EJM Van Damme, F Gorrec, F Long, G Gorkiewicz, G Hester, G Kurisu, GN Murshudov, GR Vasta, Guy Tran Van Nhieu, HL Rocchetta, Inokentijs Josts, J Henao-Mejia, J Qin, JAM Fyfe, JB Lyczak, Joel Milner, JS Lam, JU Scher, K Smith, K Zeth, Kai I. Waløen, KC Carroll, KH Caffall, L Holm, L Stewart, Laura C. McCaughey, M Ramm, M Rivera, M Shimokawa, M-F Incardona, MA Jacobs, MB Kozin, ME Spehlmann, MGK Ghequire, MGK Ghequire, MGK Ghequire, MJ Claesson, N Sharon, Nicholas P. Tucker, NR Chandra, Olwyn Byron, P Emsley, PD Adams, PV Konarev, R Grinter, R Grinter, RA Laskowski, Rhys Grinter, Richard J. Cogdell, S Mori, Sharon Kelly, SY Shaw, T Ogawa, Tom Evans, V Ovod, VB Chen, VV Ovod, VV Volkov, WF Vranken, Y Hao, Y Michel-Briand, YA Knirel   +82 more
core   +4 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules. [PDF]

, 2019
Covalent post-translational modification (PTM) of proteins with acyl groups of various carbon chain-lengths regulates diverse biological processes ranging from chromatin dynamics to subcellular localization.
Chua, Katrin F, Coan, John P, Elias, Joshua E, Gozani, Or, Krajewski, Krzysztof, Li, Tie-Mei, Strahl, Brian D, Zhang, Lichao   +7 more
core   +1 more source

Dynamic control of selectivity in the ubiquitination pathway revealed by an ASP to GLU substitution in an intra-molecular salt-bridge network [PDF]

, 2012
Ubiquitination relies on a subtle balance between selectivity and promiscuity achieved through specific interactions between ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s).
Bonvin, Alexandre M. J. J., Melquiond, Adrien S. J., Timmers, H. Th. Marc, Vries, Sjoerd J. de, Wijk, Sjoerd van   +4 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source