Results 91 to 100 of about 311,819 (318)

Review on Crystallization Strategies for Polymer Single Crystals

Polymer physics has evolved significantly over the past century, transitioning from the early recognition of the chain structure of polymers to a mature field integrating principles from statistical mechanics, thermodynamics, and condensed matter physics.
Tianyu Wu, Jun Xu, Haimu Ye
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Manipulation of charged particle beams through coherent interactions with crystals

, 2010
In the last years, the field of channeling and related phenomena aimed to particle-beam steering has received a tremendous impulse by the advent of a new generation of silicon crystals, which resulted in significant performance increase and lead to the
Mazzolari, Andrea
core  

Single Crystals of Electrically Conductive 2D MOFs: Structural and Electrical Transport Properties

, 2019
Crystalline, electrically conductive, and intrinsically porous materials are rare. Layered 2D metal-organic frameworks (MOFs) break this trend. They are porous crystals that exhibit high electrical conductivity and are novel platforms for studying ...
Lucas R., Parent, Maxx Q., Arguilla, Ivo, Stassen, Christopher H., Hendon, Nathan, Gianneschi, Robert W., Day, Mircea, Dinca, Mehdi, Rezaee, D. Kwabena, Bediako, Grigorii, Skorupskii, Philip, Kim   +10 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Metal oxide porous single crystals and other nanomaterials : an HRTEM study

, 2007
Three-dimensional porous single crystals (PSCs) are a recent development in the growing world of mesoporous material. The mesoporosity allows for the material to retain their nanoproperties whilst being bulk in size.
Dickinson, Calum
core  

Emergence of Large-Scale Magnetic-Vortices Structures by Small-Scale Helicity in Stratified Magnetized Plasma

East European Journal of Physics
In this paper, a new type of instability is identified, leading to the generation of vortex motions and magnetic fields in a plasma layer with a constant temperature gradient, subjected to uniform gravity and a vertical magnetic field.
Michael I. Kopp, Volodymyr V. Yanovsky
doaj   +1 more source

Single-crystal to single-crystal reactions [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2005
C. Hu, U. Englert
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source