Results 81 to 90 of about 810,857 (303)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Electrolytic separation of crystals of transition-metal oxides [PDF]

, 1969
Versatile flux system grows large, well-formed, stoichiometric single crystals of mixed oxides of the transition-metal elements.
Arnott, R. J., Feretti, A., Kunnamann, W.   +2 more
core   +1 more source

Antiferromagnetism in semiconducting KFe0.85Ag1.15Te2 single crystals

, 2011
We have synthesized single crystals of K1.00(3)Fe0.85(2)Ag1.15(2)Te2.0(1). The materials crystallizes in the ThCr2Si2 structure with I4/mmm symmetry and without K and Fe/Ag deficiencies, unlike in KxFe2-ySe2 and KxFe2-yS2.
C. Petrovic, Emil S. Bozin, Hechang Lei, Kefeng Wang, W. Bao   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Single Crystal Growth and Characterization of the Iron-Based Superconductor KFe2As2 Synthesized by KAs Flux Method

, 2010
Centimeter sized platelet single crystals of KFe2As2 were grown using a self-flux method. An encapsulation technique using commercial stainless steel container allowed the stable crystal growth lasting for more than 2 weeks.
Chen H., Ding H., Dong J. K., Fukazawa H., Hashimoto K., Hashimoto K., Hashimoto K., Ishida K., Kamihara Y., Kim H., Kim J. S., Luo H., Malone L., Morinaga R., Ni N., Ni N., Ni N., Reuvekamp P., Rotter M., Sasmal K., Sato T., Sefat A. S., Singh D. J., Terashima T., Terashima T., Wang X. F.   +25 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Results on the Coherent Interaction of High Energy Electrons and Photons in Oriented Single Crystals

, 2005
The CERN-NA-59 experiment examined a wide range of electromagnetic processes for multi-GeV electrons and photons interacting with oriented single crystals.
Apyan, A., Avakian, R. O., Badelek, B., Ballestrero, S., Biino, C., Birol, I., Cenci, P., Connell, S. H., Eichblatt, S., Fonseca, T., Freund, A., Gorini, B., Groess, R., Ispirian, K., Ketel, T. J., Kononets, Yu. V., Lopez, A., Mangiarotti, A., NA59 Collaboration, Sellschop, J. P. F., Shieh, M., Sona, P., Strakhovenko, V., Uggerhoj, E., Uggerhoj, U. I., Unel, G., van Rens, B., Velasco, M., Vilakazi, Z. Z., Wessely, O.   +29 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Quantum Oscillations in EuFe2As2 single crystals

, 2014
Quantum oscillation measurements can provide important information about the Fermi surface (FS) properties of strongly correlated metals. Here, we report a Shubnikov-de Haas (SdH) effect study on the pnictide parent compounds EuFe$_{2}$As$_{2}$ (Eu122 ...
Adriano, C, Balicas, L, Fisk, Z, Garitezi, TM, Grant, T, Johannes, MD, Pagliuso, PG, Rosa, PFS, Urbano, RR, Zeng, B   +9 more
core   +2 more sources