Results 1 to 10 of about 861,129 (179)
Single-domain antibody-based protein degrader for synucleinopathies [PDF]
Molecular NeurodegenerationSynucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor and neuropsychiatric symptoms.
Yixiang Jiang +7 more
doaj +5 more sources
Single domain antibody multimers confer protection against rabies infection. [PDF]
PLoS ONE, 2013 Post-exposure prophylactic (PEP) neutralizing antibodies against Rabies are the most effective way to prevent infection-related fatality. The outer envelope glycoprotein of the Rabies virus (RABV) is the most significant surface antigen for generating ...
Bhargavi M Boruah +10 more
doaj +4 more sources
Single-domain antibody screening by is PLA-seq [PDF]
Life Science Alliance, 2022 This study describes a high-sensitive, high-throughput single-domain antibody library screening approach, which is applicable for any given interested protein at single-cell resolution by is PLA-seq.
Yueyuan Yin +6 more
doaj +3 more sources
Biotechnological applications of recombinant single-domain antibody fragments [PDF]
Microbial Cell Factories, 2011 Background Single-domain antibody fragments possess structural features, such as a small dimension, an elevated stability, and the singularity of recognizing epitopes non-accessible for conventional antibodies that make them interesting for several ...
de Marco Ario
doaj +3 more sources
Single-Domain Antibody Theranostics on the Horizon. [PDF]
J Nucl Med, 2022 Single-domain antibody (sdAb) is among the most promising vectors for developing molecular imaging tracers. Several sdAb tracers targeting human epidermal growth factor receptor 2 or programmed death ligand 1 have entered clinical practice. However, radiolabeled single-valent sdAbs generally have high kidney retention, limiting their therapeutic ...
Wei W, Younis MH, Lan X, Liu J, Cai W.
europepmc +3 more sources
Single domain antibody: Development and application in biotechnology and biopharma. [PDF]
Immunol RevSummaryHeavy‐chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and comprised of two heavy chains‐only that recognize their cognate antigen by virtue of a single variable domain also referred to as VHH, single domain antibody (sdAb), or nanobody (Nb). These functional HCAbs, serendipitous discovered about three decades ago,
Yu T +4 more
europepmc +4 more sources
Development of a Chicken Immunoglobulin Heavy Chain Variable Region (VH) Single-Domain Antibody (sdAb) Against Calsequestrin (CSQ) and Its Application [PDF]
AntibodiesBackground/Objectives: Calsequestrin (CSQ) is a calcium-binding protein that is highly soluble and can serve as a solubility-enhancing fusion tag in recombinant protein expression.
Sun Lee +8 more
doaj +2 more sources
Single-domain antibodies for brain targeting [PDF]
, 2014 Smaller recombinant antibody fragments as single-domain antibodies (sdAbs) are emerging as credible alternatives because of their target specificity, high affinity, and cost-effective recombinant production. sdAbs have been forged into multivalent and multispecif ic therapeutics, or targeting moieties, that are able to shuttle their linked therapeutic ...
Lalatsa, Katerina, Moreira Leite, Diana
core +3 more sources
Single-domain antibodies make a difference [PDF]
Science, 2021 A double hit with one antibody construct may avoid viral ...
Xavier, Saelens, Bert, Schepens
openaire +2 more sources
Immunogenicity and humanization of single‐domain antibodies [PDF]
The FEBS Journal, 2021 Single‐domain antibodies (sdAbs), the autonomous variable domains of camelid and shark heavy‐chain antibodies, have many desirable properties as components of biologic drugs. However, their sequences may increase the risk of immunogenicity and antidrug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development ...
Rossotti, Martin A. +3 more
openaire +2 more sources