Results 1 to 10 of about 1,169,281 (338)

Effective Treatment of Human Breast Carcinoma Xenografts with Single-Dose²¹¹At-Labeled Anti-HER2 Single-Domain Antibody Fragment [PDF]

Journal of Nuclear Medicine, 2022
Visual Abstract Single-domain antibody fragments (sdAbs) are attractive for targeted α-particle therapy, particularly with 211At, because of their rapid accumulation in tumor and clearance from normal tissues.
Yutian Feng, Rebecca Meshaw, Xiaoguang Zhao, Stephen A. Jannetti, Ganesan Vaidyanathan, Michael R. Zalutsky   +5 more
openalex   +2 more sources

Application Progress of the Single Domain Antibody in Medicine. [PDF]

Int J Mol Sci, 2023
The camelid-derived single chain antibody (sdAb), also termed VHH or nanobody, is a unique, functional heavy (H)-chain antibody (HCAb). In contrast to conventional antibodies, sdAb is a unique antibody fragment consisting of a heavy-chain variable domain.
Tang H, Gao Y, Han J.
europepmc   +2 more sources

A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein. [PDF]

mBio, 2023
Human metapneumovirus (hMPV) is a leading cause of viral lower respiratory tract disease in children and adults. The hMPV fusion protein F is a trimeric class I fusion protein that is initially synthesized as a precursor (F0) and requires proteolytic ...
Ballegeer M, van Scherpenzeel RC, Delgado T, Iglesias-Caballero M, García Barreno B, Pandey S, Rush SA, Kolkman JA, Mas V, McLellan JS, Saelens X.   +10 more
europepmc   +2 more sources

Single Domain Antibody application in bacterial infection diagnosis and neutralization

Frontiers in Immunology, 2022
Increasing antibiotic resistance to bacterial infections causes a serious threat to human health. Efficient detection and treatment strategies are the keys to preventing and reducing bacterial infections. Due to the high affinity and antigen specificity,
Qian Qin, Qian Qin, Hao Liu, Wenbo He, Yucheng Guo, Jiaxin Zhang, Junjun She, Fang Zheng, Sicai Zhang, Serge Muyldermans, Yurong Wen, Yurong Wen   +11 more
doaj   +2 more sources

Single domain antibody multimers confer protection against rabies infection. [PDF]

PLoS ONE, 2013
Post-exposure prophylactic (PEP) neutralizing antibodies against Rabies are the most effective way to prevent infection-related fatality. The outer envelope glycoprotein of the Rabies virus (RABV) is the most significant surface antigen for generating ...
Bhargavi M Boruah, Dawei Liu, Duan Ye, Tie-Jun Gu, Chun-Lai Jiang, Mingsheng Qu, Edward Wright, Wei Wang, Wen He, Changzhen Liu, Bin Gao   +10 more
doaj   +6 more sources

Single-Domain Antibody Theranostics on the Horizon. [PDF]

J Nucl Med, 2022
Single-domain antibody (sdAb) is among the most promising vectors for developing molecular imaging tracers. Several sdAb tracers targeting human epidermal growth factor receptor 2 or programmed death ligand 1 have entered clinical practice.
Wei W, Younis MH, Lan X, Liu J, Cai W.
europepmc   +2 more sources

Single domain antibody: Development and application in biotechnology and biopharma. [PDF]

Immunol Rev
Heavy‐chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and comprised of two heavy chains‐only that recognize their cognate antigen by virtue of a single variable domain also referred to as VHH, single domain antibody (sdAb)
Yu T, Zheng F, He W, Muyldermans S, Wen Y.   +4 more
europepmc   +2 more sources

Structure-guided discovery of a single-domain antibody agonist against human apelin receptor [PDF]

Science Advances, 2020
We converted a potent antagonistic sdAb JN241 to an agonistic sdAb JN241-9 to human APJ by structure-guided rational design. Developing antibody agonists targeting the human apelin receptor (APJ) is a promising therapeutic approach for the treatment of ...
Yanbin Ma, Yao Ding, Xianqiang Song, Xiaochuan Ma, Xun Li, Ning Zhang, Yunpeng Song, Yaping Sun, Yuqing Shen, Wenge Zhong, Liaoyuan A. Hu, Yingli Ma, Mei-Yun Zhang   +12 more
openalex   +2 more sources

Stabilization of a Broadly Neutralizing Anti-Chikungunya Virus Single Domain Antibody

Frontiers in Medicine, 2021
A single domain antibody (clone CC3) previously found to neutralize a vaccine strain of the chikungunya virus (PRNT50 = 2. 5 ng/mL) was found to be broadly neutralizing.
Jinny L. Liu, Emily M. Webb, Dan Zabetakis, Crystal W. Burke, Christina L. Gardner, Pamela J. Glass, Patricia M. Legler, James Weger-Lucarelli, George P. Anderson, Ellen R. Goldman   +9 more
doaj   +2 more sources

Fully human single-domain antibody targeting a highly conserved cryptic epitope on the Nipah virus G protein. [PDF]

Nat Commun
Nipah virus infection, one of the top priority diseases recognized by the World Health Organization, underscores the urgent need to develop effective countermeasures against potential epidemics and pandemics. Here, we identify a fully human single-domain
Wang Y, Sun Y, Shen Z, Wang C, Qian J, Mao Q, Wang Y, Song W, Kong Y, Zhan C, Chen Z, Dimitrov DS, Yang Z, Jiang S, Wu F, Lu L, Ying T, Sun L, Wu Y.   +18 more
europepmc   +2 more sources