Results 11 to 20 of about 1,169,281 (338)

Bivalent single domain antibody constructs for effective neutralization of Venezuelan equine encephalitis [PDF]

Scientific Reports, 2022
Venezuelan equine encephalitis virus (VEEV) is a mosquito borne alphavirus which leads to high viremia in equines followed by lethal encephalitis and lateral spread to humans.
Jinny L. Liu, Dan Zabetakis, Christina L. Gardner, Crystal W. Burke, Pamela J. Glass, Emily M. Webb, Lisa C. Shriver-Lake, George P. Anderson, James Weger-Lucarelli, Ellen R. Goldman   +9 more
doaj   +2 more sources

Single-domain antibody-based protein degrader for synucleinopathies [PDF]

Molecular Neurodegeneration
Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor and neuropsychiatric symptoms.
Yixiang Jiang, Yan Lin, Amber M. Tetlow, Ruimin Pan, Changyi Ji, Xiang-Peng Kong, Erin E. Congdon, Einar M. Sigurdsson   +7 more
doaj   +2 more sources

Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection [PDF]

Frontiers in Immunology, 2019
Lower respiratory tract infections, such as infections caused by influenza A viruses, are a constant threat for public health. Antivirals are indispensable to control disease caused by epidemic as well as pandemic influenza A.
D. De Vlieger, Katja Hoffmann, I. Van Molle, W. Nerinckx, Lien Van Hoecke, M. Ballegeer, Sarah Creytens, H. Remaut, H. Hengel, Bert Schepens, X. Saelens   +10 more
semanticscholar   +3 more sources

Multimeric single-domain antibody complexes protect against bunyavirus infections

eLife, 2020
The World Health Organization has included three bunyaviruses posing an increasing threat to human health on the Blueprint list of viruses likely to cause major epidemics and for which no, or insufficient countermeasures exist.
Paul J Wichgers Schreur, Sandra van de Water, Michiel Harmsen, Erick Bermúdez-Méndez, Dubravka Drabek, Frank Grosveld, Kerstin Wernike, Martin Beer, Andrea Aebischer, Olalekan Daramola, Sara Rodriguez Conde, Karen Brennan, Dorota Kozub, Maiken Søndergaard Kristiansen, Kieran K Mistry, Ziyan Deng, Jan Hellert, Pablo Guardado-Calvo, Félix A Rey, Lucien van Keulen, Jeroen Kortekaas   +20 more
doaj   +2 more sources

Bamboo Shark as a Small Animal Model for Single Domain Antibody Production

Frontiers in Bioengineering and Biotechnology, 2021
The development of shark single domain antibodies (sdAbs) is hindered by the high cost and tediousness of large-sized shark farming. Here, we demonstrated white-spotted bamboo sharks (Chiloscyllium plagiosum) being cultivated commercially as a promising ...
Likun Wei, Meiniang Wang, Meiniang Wang, Haitao Xiang, Haitao Xiang, Haitao Xiang, Yuan Jiang, Jinhua Gong, Dan Su, M. A. R. Al Azad, Hongming Dong, Hongming Dong, Hongming Dong, Limin Feng, Jiajun Wu, Leo Lai Chan, Leo Lai Chan, Naibo Yang, Naibo Yang, Naibo Yang, Jiahai Shi, Jiahai Shi, Jiahai Shi, Jiahai Shi, Jiahai Shi   +24 more
doaj   +2 more sources

Development of a Chicken Immunoglobulin Heavy Chain Variable Region (VH) Single-Domain Antibody (sdAb) Against Calsequestrin (CSQ) and Its Application [PDF]

Antibodies
Background/Objectives: Calsequestrin (CSQ) is a calcium-binding protein that is highly soluble and can serve as a solubility-enhancing fusion tag in recombinant protein expression.
Sun Lee, Seoryeong Park, Hyunji Yang, Geummi Cho, Seung Youn Lee, Donggeun Lee, Nara Tae, Dae Hee Kim, Junho Chung   +8 more
doaj   +2 more sources

Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice Studies

ACS Chemical Neuroscience, 2019
Tau is a neuronal protein linked to pathologies called tauopathies, including Alzheimer's disease. In Alzheimer's disease, tau aggregates into filaments leading to the observation of intraneuronal fibrillary tangles. Molecular mechanisms resulting in tau
Elian Dupré, Clément Danis, Alexis Arrial, Xavier Hanoulle, Mégane Homa, François‐Xavier Cantrelle, Hamida Merzougui, Morvane Colin, Jean‐Christophe Rain, Luc Buée, Isabelle Landrieu   +10 more
openalex   +3 more sources

Preparation and characterization of a single-domain antibody specific for the porcine epidemic diarrhea virus spike protein

AMB Express, 2019
Porcine epidemic diarrhea (PED) is a diarrheal disease of swine caused by porcine epidemic diarrhea virus (PEDV). It is characterized by acute watery diarrhea, dehydration and vomiting in swine of all ages and is especially fatal for neonatal and ...
Fuxiang Bao, Lixin Wang, Xinxin Zhao, Ting Lu, A. Mi Na, Xuefei Wang, Jinshan Cao, Yanan Du   +7 more
doaj   +2 more sources

Kinetic Characterisation of a Single Chain Antibody against the Hormone Abscisic Acid: Comparison with Its Parental Monoclonal [PDF]

, 2016
A single-chain Fv fragment antibody (scFv) specific for the plant hormone abscisic acid (ABA) has been expressed in the bacterium Escherichia coli as a fusion protein.
A Hayhurst, A Sadanandom, A Wörn, AM Jones, Andrew J. Thompson, Andrew Marsh, B Kazemier, D Missiakas, DG Myszka, DG Myszka, DM Hoover, Ellen R Goldman, George O. Badescu, GM Banowetz, J Messens, J Phillips, J Wigger, LLH Christensen, M Malmqvist, MK Walker-Simmons, O Artsaenko, O Artsaenko, P Jurado, P Martineau, PB Luppa, Q Li, R Mertens, R Raag, R Waadt, Richard M. Napier, S Shaki-Loewensteina, SA Quarrie, SA Quarrie, SM Kipriyanova, Timothy R. Smith, TR Smith, UL Jönsson, WFM Stöcklein, Y-W Li   +38 more
core   +28 more sources

Humanized single-domain antibody targeting HER2 enhances function of chimeric antigen receptor T cells. [PDF]

Front Immunol, 2023
Zheng R, Chen Y, Zhang Y, Liang S, Zhao X, Wang Y, Wang P, Meng R, Yang A, Yan B.   +9 more
europepmc   +3 more sources