Results 111 to 120 of about 18,085,785 (304)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mitigation of Single Event Upset Effects in Nanosheet FET 6T SRAM Cell

IEEE Access
The effects of single event upset (SEU) by alpha particles and heavy ions on the data flip of a 3 nm technology node gate-all-around (GAA) nanosheet field-effect transistor (NSFET) 6T static random-access memory (SRAM) cell was studied through technology
Minji Bang, Jonghyeon Ha, Minki Suh, Dabok Lee, Minsang Ryu, Jin-Woo Han, Hyunchul Sagong, Hojoon Lee, Jungsik Kim   +8 more
doaj   +1 more source

Simulation of 50-500 MeV Quasi-monoenergetic Neutron Source for Single Event Effect Irradiation Experiment

Yuanzineng kexue jishu, 2023
The neutron-induced single event effect affects the reliability of electronic devices used in aircraft and ground nuclear facilities. With the progress of semiconductor technology, device feature sizes become smaller and more integrated, radiation ...
CHEN Qiming;GUO Gang;HAN Jinhua;ZHAO Shuyong;MA Xu;ZHANG Zheng;LIU Jiancheng
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Current Single Event Effects Results for Candidate Spacecraft Electronics for NASA

, 2004
We present data on the vulnerability of a variety of candidate spacecraft electronics to proton and heavy ion induced single event effects.
Sanders, Anthony B., Marshall, Cheryl J., Hawkins, Donald K., OBryan, Martha V., Reed, Robert A., Kniffin, Scott D., Cox, Stephen R., Seidleck, Christina M., Carts, Martin A., LaBel, Kenneth A.   +9 more
core  

NASA Goddard Space Flight Center's Compendium of Recent Single Event Effects Results [PDF]

, 2018
We present the results of single event effects (SEE) testing and analysis investigating the effects of radiation on electronics.
Wilcox, Edward P., Topper, Alyson D., Casey, Megan C., Pellish, Jonathan A., Wyrwas, Edward J., Lewellen, John W., O'Bryan, Martha V., Campola, Michael J., Lauenstein, Jean-Marie, Holloway, Michael A., Berg, Melanie D., Szabo, Carl M., LaBel, Kenneth A., Chen, Dakai   +13 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Current Single Event Effects Compendium of Candidate Spacecraft Electronics for NASA [PDF]

, 2010
We present the results of single event effects (SEE) testing and analysis investigating the effects of radiation on electronics.
Pearce, Larry G., Satterfield, Harold W., Burns, Sam, Salzman, James F., Pellish, Jonathan A., Oldham, Timothy R., Sanders, Anthony B., Berg, Melanie, Ladbury, Ray L., Buchner, Stephen P., Lauenstein, Jean-Marie, Phan, Anthony M., LaBel, Kenneth A., Marshall, Paul, Bernard, Theju M., Irom, Farokh, vonVonno, Nick W., Williams, Alan P., Marshall, Cheryl, Kim, Hak S., O'Bryan, Martha V., Thomson, Eric T., Carts, Martin A., Chen, Dakai, Xapsos, Michael A.   +24 more
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source