Results 171 to 180 of about 2,968,943 (344)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Compendium of Single Event Effects Results for Candidate Spacecraft Electronics for NASA [PDF]

, 2006
Martha V. O'Bryan, Hak S. Poivey, S.D. Kniffin, S. Büchner, Ray Ladbury, Timothy R. Oldham, James W. Howard, Kenneth A. LaBel, Anthony B. Sanders, Melanie D. Berg, Cheryl J. Marshall, Paul W. Marshall, Hak Kim, Anthony Dung-phan, Donald K. Hawkins, Martin A. Carts, James Forney, Tim Irwin, C.M. Seidleck, S. F. J. Cox, M. Friendlich, Ryan J Flanigan, Dave Petrick, Wes Powell, Jeremy Karsh, M.P. Baze   +25 more
openalex   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Critical evaluation of the pulsed laser method for single event effects testing and fundamental studies

, 1994
Joseph S. Melinger, S. Büchner, Dale McMorrow, W.J. Stapor, T.R. Weatherford, A.B. Campbell, Harvey Eisen   +6 more
openalex   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Study on Single-Event Effects and Hardening Analysis of Frequency Divider Circuits Based on InP HBT Process. [PDF]

Micromachines (Basel)
Zhao X, Su Y, Chen Y, Zhang Y, Xiang J, Cheng S, Bai Y.   +6 more
europepmc   +1 more source

Performance of the high-energy single-event effects test Facility (SEETF) at Michigan State university's national Superconducting Cyclotron laboratory (NSCL) [PDF]

, 2004
Ray Ladbury, Robert A. Reed, Paul W. Marshall, K.A. LaBel, R. Anantaraman, Ron Fox, D. Sanderson, A. Stolz, J. Yurkon, A. Zeller, J. Stetson   +10 more
openalex   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source