Results 121 to 130 of about 214,395 (302)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Evaluation of alternative discrete-event simulation experimental methods

The aim of the research was to assist non-experts produce meaningful, non-terminating discrete event simulations studies. The exemplar used was manufacturing applications, in particular sequential production lines.
Warn, Alan James
core  

The Atacama Cosmology Telescope: Systematic Transient Search of Single Observation Maps

The Astrophysical Journal
We conduct a systematic search for astrophysical transients using data from the Atacama Cosmology Telescope. The data were taken from 2017 to 2022 in three frequency bands spanning 77 to 277 GHz.
Emily Biermann, Yaqiong Li, Sigurd Naess, Steve K. Choi, Susan E. Clark, Mark Devlin, Jo Dunkley, P. A. Gallardo, Yilun Guan, Allen Foster, Matthew Hasselfield, Carlos Hervías-Caimapo, Matt Hilton, Adam D. Hincks, Anna Y. Q. Ho, John C. Hood II, Kevin M. Huffenberger, Arthur Kosowsky, Michael D. Niemack, John Orlowski-Scherer, Lyman Page, Bruce Partridge, Maria Salatino, Cristóbal Sifón, Suzanne T. Staggs, Cristian Vargas, Edward J. Wollack   +26 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Single Event Transient Injection on an Operational Amplifier: A Case Study

, 2008
—This paper reports a case study about effects produced by the radiation Single Event Transient (SET) injection on a custom operational amplifier. SETs were injected in the operational amplifier transistors in order to evaluate their sensitivity to the ...
John M. Espinosa-duran, I. Introduction, Gloria Huertas, Jose L. Huertas, Jaime Velasco-medina, Raoul Velazco   +5 more
core  

Single event transient effects in raised source/drain double-gate 1-T DRAM

Single event transient (SET) due to heavy ion strike is a major reliability concern in digital VLSI circuits. In this paper, the SET effects in a capacitorless 1-T DRAM with raised source/drain double-gate MOSFET are analyzed.
Asenov, Asen, Aneesh, Y. M., Bindu, B.
core   +1 more source

A Procedure for Fast Circuit Cross Section Estimation

Chips
Semiconductor technologies are susceptible to radiation effects. The particle incidence in susceptible areas of an integrated circuit (IC) can generate physical interactions capable of producing errors.
Clayton R. Farias, Tiago R. Balen, Paulo F. Butzen   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Single event transient injection on an operational amplifier: a case study

, 2007
International audienceThis paper reports a case study about effects produced by the radiation Single Event Transient (SET) injection on a custom operational amplifier. SETs were injected in the operational amplifier transistors in order to evaluate their
Huertas, J.L., Velazco, Raoul, Espinosa-Duran, J.M., Huertas, G., Velasco-Medina, J.   +4 more
core  

Single Event Induced Voltage Transients within lnP HBT Circuits [PDF]

, 2000
Voltage transients internal to an InP HBT integrated circuit are measured with picosecond resolution. Results show that the single event "shorts" the transistor terminals and the transient response can produce multiple errors at gigahertz ...
Whitaker, J., Thomas, S. III, Elliott, K., Bustamante, M., Weatherford, T.R., Meyer, S.   +5 more
core