Results 121 to 130 of about 8,243,533 (301)

Effects of the total ionizing dose on the single event transient sensitivity of SiGe HBT exposed to heavy-ion beam

The synergistic effects of the total ionizing dose (TID) on sensitivity to a single event transient (SET) of the silicon-germanium heterojunction bipolar transistors (SiGe HBTs) are investigated in a series of irradiation tests.
Guo, Hongxia (author), Wu, Xianxiang (author), Hajdas, Wojciech (author), Yan, Yunyi (author), Wang, Hui (author), Wang, Xin (author), Zhang, Jinxin (author), Feng, Juan (author)   +7 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The Atacama Cosmology Telescope: Systematic Transient Search of Single Observation Maps

The Astrophysical Journal
We conduct a systematic search for astrophysical transients using data from the Atacama Cosmology Telescope. The data were taken from 2017 to 2022 in three frequency bands spanning 77 to 277 GHz.
Emily Biermann, Yaqiong Li, Sigurd Naess, Steve K. Choi, Susan E. Clark, Mark Devlin, Jo Dunkley, P. A. Gallardo, Yilun Guan, Allen Foster, Matthew Hasselfield, Carlos Hervías-Caimapo, Matt Hilton, Adam D. Hincks, Anna Y. Q. Ho, John C. Hood II, Kevin M. Huffenberger, Arthur Kosowsky, Michael D. Niemack, John Orlowski-Scherer, Lyman Page, Bruce Partridge, Maria Salatino, Cristóbal Sifón, Suzanne T. Staggs, Cristian Vargas, Edward J. Wollack   +26 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

A Procedure for Fast Circuit Cross Section Estimation

Chips
Semiconductor technologies are susceptible to radiation effects. The particle incidence in susceptible areas of an integrated circuit (IC) can generate physical interactions capable of producing errors.
Clayton R. Farias, Tiago R. Balen, Paulo F. Butzen   +2 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Single-event transient analysis on radiation-hardened SiGe and GaN ringfet’s using 3D TCAD simulations

Discover Materials
The ringFET devices are investigated for radiation-hardened applications employing advanced semiconductor materials such as SiGe and GaN by conducting 3D TCAD simulations.
M. Ramya, K. K. Nagarajan, R. Binowesley, A. J. Bhuvaneshwari, P. Kaythry, K. J. Jegadish Kumar, R. Vinu, C. Parthasarathy, S. Gomathi   +8 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source