Results 41 to 50 of about 12,854,075 (243)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A Procedure for Fast Circuit Cross Section Estimation

Chips
Semiconductor technologies are susceptible to radiation effects. The particle incidence in susceptible areas of an integrated circuit (IC) can generate physical interactions capable of producing errors.
Clayton R. Farias, Tiago R. Balen, Paulo F. Butzen   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Bedload transport controls bedrock erosion under sediment-starved conditions [PDF]

Earth Surface Dynamics, 2015
Fluvial bedrock incision constrains the pace of mountainous landscape evolution. Bedrock erosion processes have been described with incision models that are widely applied in river-reach and catchment-scale studies.
A. R. Beer, J. M. Turowski
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Xilinx Kintex-UltraScale Field Programmable Gate Array Single Event Effects (SEE) Heavy-Ion Test Report [PDF]

, 2018
This is an independent investigation that evaluates the single event destructive and transient susceptibility of the Xilinx Kintex-UltraScale device. Design/Device susceptibility is determined by monitoring the device under test (DUT) for Single Event ...
Seidleck, Christina, Campola, Michael, Berg, Melanie, Label, Ken, Phan, Anthony, Kim, Hak   +5 more
core  

Steady-state visual evoked potentials can be explained by temporal superposition of transient event-related responses [PDF]

, 2011
<p><b>Background:</b> One common criterion for classifying electrophysiological brain responses is based on the distinction between transient (i.e. event-related potentials, ERPs) and steady-state responses (SSRs).
Paula Pazo-Alvarez, Gross, J., Pazo-Alvarez Paula, Darriba, Álvaro, Darriba Alvaro, Darriba, A., Pablo Campo, Gross, Joachim, Pazo-Álvarez, Paula, Capilla, Almudena, Gross Joachim, Campo, P., Campo, Pablo, Capilla, A., Campo Pablo, Valdes-Sosa, P.A., Almudena Capilla, Darriba Domínguez, Álvaro, Capilla González, Almudena, Alvaro Darriba, Capilla Almudena, Joachim Gross, Pazo-Alvarez, P., Campo Martínez-Lage, Pablo, Pazo Álvarez, Paula   +24 more
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A two for one special: EEG hyperscanning using a single-person EEG recording setup

MethodsX, 2023
EEG hyperscanning refers to recording electroencephalographic (EEG) data from multiple participants simultaneously. Many hyperscanning experimental designs seek to mimic naturalistic behavior, relying on unpredictable participant-generated stimuli.
Caitriona L. Douglas, Antoine Tremblay, Aaron J. Newman   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source