Results 91 to 100 of about 310,837 (298)
Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA [PDF]
, 2002 Xiaoqi Liu, Raymond L. Erikson
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Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks
Advanced Functional Materials, EarlyView.This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson +12 more
wiley +1 more source
RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase [PDF]
, 2002 Olivier Donzé
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Advanced Functional Materials, EarlyView.The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar +6 more
wiley +1 more source
Journal of Inflammation Research, 2023 YiFu Tian,1 CaiXia Zhou,1 XiaoYang Bu,1 Qian Lv,1 Qin Huang1,2 1Department of Physiology of Basic Medical Sciences, Guangxi Medical University, Nanning, People’s Republic of China; 2Department of Key Laboratory of Longevity and Aging-Related Diseases of ...
Tian Y, Zhou C, Bu X, Lv Q, Huang Q
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Metal Nanoclusters for Cancer Imaging and Treatment
Advanced Functional Materials, EarlyView.This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu +5 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...
Yelixza I. Avila +7 more
wiley +1 more source
Therapeutics and Clinical Risk Management, 2023 Stacy Dixon, Xuan Kang, Dianna Quan Department of Neurology, University of Colorado, Aurora, CO, USACorrespondence: Dianna Quan, Department of Neurology - University of Colorado, 12631 East 17th Avenue, Mailstop B185, Aurora, CO, 80045, USA, Tel +1 (303)
Dixon S, Kang X, Quan D
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Advanced Functional Materials, EarlyView.Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu +7 more
wiley +1 more source