Results 141 to 150 of about 497,452 (342)
Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway [PDF]
, 2003 Torgeir Holen
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Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Simultaneous inhibition of GSK3α and GSK3β using hairpin siRNA expression vectors [PDF]
, 2003 Jenn‐Yah Yu +4 more
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Advanced Healthcare Materials, EarlyView.Hybrid NPs are developed as efficient, scalable nanocarriers for in vitro microRNA delivery, ensuring high loading efficiency, controlled release, physiological and long‐term storage stability. They outperform commercial lipid‐based reagents in terms of transfection efficiency and biocompatibility.
Letizia Nicoletti +11 more
wiley +1 more source
An siRNA ribonucleoprotein is found associated with polyribosomes in Trypanosoma brucei [PDF]
, 2003 Appolinaire Djikeng +4 more
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Advanced Materials, EarlyView.This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle +9 more
wiley +1 more source
Control of siRNA expression utilizing Cre-loxP recombination system [PDF]
, 2003 Vivi Kasim +2 more
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Precision delivery of RAS-inhibiting siRNA to KRAS driven cancer via peptide-based nanoparticles [PDF]
, 2019 Over 95% of pancreatic adenocarcinomas (PDACs), as well as a large fraction of other tumor types, such as colorectal adenocarcinoma, are driven by KRAS activation. However, no direct RAS inhibitors exist for cancer therapy.
Bi, Ye +14 more
core +1 more source
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
Simple and rapid synthesis of siRNA derived from in vitro transcribed shRNA [PDF]
, 2003 Takayuki Katoh +5 more
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