Results 201 to 210 of about 310,837 (298)

Articles selected by Faculty of 1000: profiling flowers; targeted transgenesis in Drosophila; aging and oxidation in plants; membrane protein localization in E. coli; immune response to siRNAs [PDF]

, 2004

openalex   +1 more source

PROS1‐MERTK Axis Drives Tumor Microenvironment Crosstalk and Progression in Papillary Thyroid Microcarcinoma

Advanced Science, EarlyView.
Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang, Ye Zhang, Zhu Liu, Zhiyuan Wang, Huaqin Wang, Xiaoyu Ji, Hongyue Su, Fan Yang, Lirong Yan, Ying Xu, Hao Zhang, Wei Sun   +11 more
wiley   +1 more source

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes. [PDF]

Nat Cell Biol
Wu Z, Xue Y, Wang S, Shih YH, Zhong Z, Feng S, Draper J, Lu A, Hoeke CA, Sha J, Li L, Wohlschlegel J, Wu K, Jacobsen SE.   +13 more
europepmc   +1 more source

Articles selected by Faculty of 1000: chromosome pairing in Arabidopsis; hybrid inviability in birds and mammals; endogenous siRNAs in Arabidopsis; evolution of sex-biased genes in Drosophila; human patterns of genetic variation [PDF]

, 2004

openalex   +1 more source

piR‐RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX‐1 Cytoplasm Localization

Advanced Science, EarlyView.
PIWI‐interacting RNAs (piRNAs), a novel category of small non‐coding RNAs, have been implicated in the development of various diseases. This study explores the tumor‐suppressive mechanism of a downregulated piRNA (designated piR‐RCC) in renal cell carcinoma (RCC), and provides a delivery strategy targeting RCC tumor by constructing a cell membrane ...
Ruyue Wang, Fan Li, Yudong Lin, Zeyi Lu, Wenqin Luo, Zhehao Xu, Ziwei Zhu, Yi Lu, Xudong Mao, Yang Li, Zhinian Shen, Haohua Lu, Yining Chen, Liqun Xia, Mingchao Wang, Lifeng Ding, Gonghui Li   +16 more
wiley   +1 more source

Optimization of a synthetic siRNA delivery for the treatment of rhabdomyosarcoma

Open Life Sciences, 2008
Lesko Ewa, Miekus Katarzyna, Grabowska Agnieszka, Gładys Aleksandra, Majka Marcin   +4 more
doaj   +1 more source

Protection from malaria infection using liver-targeted siRNA. [PDF]

Mol Ther Methods Clin Dev
Steel RWJ, Schepis A, Nguyen T, Milstein S, Yucius K, Tu HC, Fishilevich E, Haslett P, Kappe SHI.   +8 more
europepmc   +1 more source

RIG‐I‐Inducing Small Molecules Potently Inhibit HMA‐Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Advanced Science, EarlyView.
This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen, Jiaqi Wu, Yuntong Li, Jiayu Huang, Xiangqin Weng, Jiale Wu, Shujun Xiao, Huaxin Song, Zhengyuan Wang, Ni Yan, Fangfang Shi, Derun Zheng, Kai Tan, Hesong Zhang, Jingyi Cui, Wen Wu, Wei Wu, Sujiang Zhang, Min Lu   +18 more
wiley   +1 more source

[Corrigendum] Human chorionic gonadotropin β regulates epithelial‑mesenchymal transition and metastasis in human ovarian cancer. [PDF]

Oncol Rep
Liu N, Peng SM, Zhan GX, Yu J, Wu WM, Gao H, Li XF, Guo XQ.   +7 more
europepmc   +1 more source