Results 251 to 260 of about 497,452 (342)

Inhibition of influenza virus matrix (M1) protein expression and virus replication by U6 promoter-driven and lentivirus-mediated delivery of siRNA

, 2004
Eric Ka‐Wai Hui, Ee Ming Yap, Dong Sung An, Irvin S. Y. Chen, Debi P. Nayak   +4 more
openalex   +1 more source

Targeting PFKFB4 Biomimetic Codelivery System Synergistically Enhances Ferroptosis to Suppress Small Cell Lung Cancer and Augments the Efficacy of Anti‐PD‐L1 Immunotherapy

Advanced Science, EarlyView.
In this study, a targeting PFKFB4 biomimetic codelivery system is developed to improve paclitaxel efficacy by inducing ferroptosis in SCLC. This system enhances immune cell infiltration and cytokine secretion, activating anti‐tumor immunity. Combined with anti‐PD‐L1, it boosts immune responses, offering a novel therapeutic strategy for overcoming ...
Xiang Liu, Jingjun He, Haoxuan Ying, Cuiying Chen, Chongyang Zheng, Peng Luo, Weiliang Zhu, Ting Wei, Bufu Tang, Jian Zhang   +9 more
wiley   +1 more source

Kinome screening identifies integrated stress response kinase EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling. [PDF]

Sci Adv
Singh PK, Agarwal S, Volpi I, Wilhelm LP, Becchi G, Keenlyside A, Macartney T, Toth R, Rousseau A, Masson GR, Ganley IG, Muqit MMK.   +11 more
europepmc   +1 more source

PRMT1‐Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
PRMT1 drives carboplatin resistance and tumor progression in head and neck squamous cell carcinoma (HNSCC) through a novel, methyltransferase‐independent mechanism. It recruits the SWI/SNF complex to activate IGF2BP2, promoting tumor growth and carboplatin resistance. PBX2 upregulates PRMT1, reinforcing this pathway. This study uncovers a non‐catalytic
Shixian Liu, Wentao Zhang, Weiwei Liu, Zhao Ding, Ruijing Zhang, Yuefeng Han, Zihao Niu, Mengdie Zhang, Hui Li, Dapeng Li, Zixi Wang, Jie Peng, Yu Wu, Yanxun Han, Zihui Xie, Jing Wu, Liang Qin, Zhongdong Hu, Xu Chen, Yunlong Hu, Yehai Liu, Shiyin Ma, Xiaojun Zha   +22 more
wiley   +1 more source

Exosome Enveloped by Nano Lipid Particle a New Model for Signal Transducer and Activator of Transcription 3 Silencer Ribonucleic Acid Delivery System to a Glioblastoma Mice Model. [PDF]

Cancers (Basel)
Monfaredan A, Şen S, Hosseininasab A, Taştekin D, Fazli G, Bozbey HU, Yousefi N, Hocaoğlu M, Öncül MO, Özen RS.   +9 more
europepmc   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Mesenchymal stem cells improve osteoarthritis by secreting superoxide dismutase to regulate oxidative stress response. [PDF]

BMC Musculoskelet Disord
Yao Y, Cao J, Ding C.
europepmc   +1 more source

High-Throughput siRNA-Based Functional Target Validation

, 2004
Xin Hong, Alejandro Bernal, Frank A. Amato, Albert Pinhasov, Jack A. Kauffman, Douglas E. Brenneman, Claudia K. Derian, Patricia Andrade‐Gordon, Carlos R. Plata‐Saláman, Sergey E. Ilyin   +9 more
openalex   +1 more source

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source