Results 261 to 270 of about 527,047 (339)

Nanoparticle-based siRNA Delivery System in Intestine Empowers the Obesity Management [PDF]

Jianshe Yang
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Optimization of a synthetic siRNA delivery for the treatment of rhabdomyosarcoma

Open Life Sciences, 2008
Lesko Ewa, Miekus Katarzyna, Grabowska Agnieszka, Gładys Aleksandra, Majka Marcin   +4 more
doaj   +1 more source

Respiratory Delivery of Highly Conserved Antiviral siRNAs Suppress SARS-CoV-2 Infection. [PDF]

Int J Mol Sci
Zhang Y, Johansen MD, Ledger S, Turville S, Thordarson P, Hansbro PM, Kelleher AD, Ahlenstiel CL.   +7 more
europepmc   +1 more source

Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6

, 2014
Gareth D. Healey, Jennifer A. Lockridge, Shawn Zinnen, Julian M. Hopkin, I M Richards, William Walker   +5 more
openalex   +2 more sources

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Correction: ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma. [PDF]

Sci Rep
Ran L, Mou X, Peng Z, Li X, Li M, Xu D, Yang Z, Sun X, Yin T.   +8 more
europepmc   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

The lncRNA PARylator promotes PARP1 activation and resistance to DNA‑damaging therapy in esophageal squamous cell carcinoma. [PDF]

Exp Hematol Oncol
Qi TF, Liu Y, Yang J, Yue YM, Han MM, Liu H, Li J, Liu M, Zhang Y, Kou JH, Li WJ, Liu X, La T, Liu T, Chen S, Zhang XD, Cang S, Teng L, Fan T.   +18 more
europepmc   +1 more source

Nanoparticules lipidiques pH-sensibles basées sur une bascule moléculaire pour la délivrance intracytoplasmique de siRNA

, 2016
Warren Viricel
openalex   +1 more source