Results 271 to 280 of about 497,452 (342)

Twist1 Regulates the Immune Checkpoint VISTA and Promotes the Proliferation, Migration and Progression of Pancreatic Cancer Cells. [PDF]

J Cell Mol Med
Topcu KSB, Cacan E.
europepmc   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

CAVIN3 deficiency promotes vascular normalization in ocular neovascular disease via ERK/JAG1 signaling pathway. [PDF]

JCI Insight
Li W, Zhang Y, Zhu H, Su N, Sun R, Mao X, Yang Q, Yuan S.   +7 more
europepmc   +1 more source

siRNA reproducibility.

BioTechniques, 2011
openaire   +2 more sources

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source

Recent Update on siRNA Therapeutics. [PDF]

Int J Mol Sci
Ebenezer O, Oyebamiji AK, Olanlokun JO, Tuszynski JA, Wong GK.   +4 more
europepmc   +1 more source

Development of delivery system for siRNA using atelocollagen as a carrier material

, 2004
Yoshiko Minakuchi, Fumitaka Takeshita, Shunji Nagahara, Takahiro Ochiya   +3 more
openalex   +2 more sources

Targeted knockdown of canine KIT (stem cell factor receptor) using small interfering RNA [PDF]

, 2010
Argyle, D., Catchpole, B., Elders, Richard, Holder, A.   +3 more
core  

Organization of the Proteostasis Network of Membraneless Organelles

Advanced Science, EarlyView.
A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim, Yuqi Bian, Alicia González Díaz, Frank Pun, Alex Zhavoronkov, Richard I. Morimoto, Michele Vendruscolo   +6 more
wiley   +1 more source

Small interfering RNA: From designing to therapeutic in cancer. [PDF]

J Genet Eng Biotechnol
Singh J, Saeedan AS, Kaithwas G, Ansari MN.   +3 more
europepmc   +1 more source