Results 281 to 290 of about 310,837 (298)
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Drug Discovery Today: Technologies, 2010
siRNA technology has not only greatly facilitated functional characterization of new genes, but also presented tremendous potential for becoming the next generation of blockbuster drugs. The technology has penetrated life science research in an extremely fast speed, thus providing a huge knowledge base for siRNA drug development.
Quan Du +3 more
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siRNA technology has not only greatly facilitated functional characterization of new genes, but also presented tremendous potential for becoming the next generation of blockbuster drugs. The technology has penetrated life science research in an extremely fast speed, thus providing a huge knowledge base for siRNA drug development.
Quan Du +3 more
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Nature Biotechnology, 2008
Leukocyte-directed, small interfering (si)RNA against cyclin D1 shows promise for treatment of inflammatory bowel disease.
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Leukocyte-directed, small interfering (si)RNA against cyclin D1 shows promise for treatment of inflammatory bowel disease.
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Targeting Oncogenes with siRNAs
2008Current cancer chemotherapies heavily rely on the unspecific inhibition of proliferating cells. This lack of tumour cell specificity results in severe toxic side effects and may only hardly affect quiescent cancer stem cells consequently leading to relapse. Since oncogenes are exclusively expressed in malignant and pre-malignant cells, they may provide
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Nature Biotechnology, 2005
Abstract Two new studies describe strategies for increasing the efficiency of RNA interference.
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Abstract Two new studies describe strategies for increasing the efficiency of RNA interference.
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2004
RNA interference is the process that double-stranded RNA (dsRNA) induces the homology-dependent degradation of cognate mRNA mediated by 21- to 23-nt small interfering RNA (siRNA). Successful application of RNAi in functional genomics and proteomics, cancer gene therapy, and virus protection depends on the efficient delivery of siRNA into mammalian ...
Sven N. Reske, Changxian Shen
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RNA interference is the process that double-stranded RNA (dsRNA) induces the homology-dependent degradation of cognate mRNA mediated by 21- to 23-nt small interfering RNA (siRNA). Successful application of RNAi in functional genomics and proteomics, cancer gene therapy, and virus protection depends on the efficient delivery of siRNA into mammalian ...
Sven N. Reske, Changxian Shen
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Chitosan/siRNA Nanoparticles Encapsulated in PLGA Nanofibers for siRNA Delivery
ACS Nano, 2012Composite nanofibers of biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) encapsulating chitosan/siRNA nanoparticles (NPs) were prepared by electrospinning. Acidic/alkaline hydrolysis and a bulk/surface degradation mechanism were investigated in order to achieve an optimized release profile for prolonged and efficient gene silencing.
Chen, Menglin +7 more
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2009
With the recent discovery of small interfering RNA (siRNA), to silence the expression of genes in vitro and in vivo, there has been a need to deliver these molecules to the cell nucleus. Forming a lipid/nucleic acid complex has become a solution and is explored here.
Ryan Mesaros +2 more
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With the recent discovery of small interfering RNA (siRNA), to silence the expression of genes in vitro and in vivo, there has been a need to deliver these molecules to the cell nucleus. Forming a lipid/nucleic acid complex has become a solution and is explored here.
Ryan Mesaros +2 more
openaire +3 more sources
Nature Methods, 2006
A new study addresses how to design highly specific small interfering RNAs (siRNAs) capable of distinguishing between similar variants of the same gene.
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A new study addresses how to design highly specific small interfering RNAs (siRNAs) capable of distinguishing between similar variants of the same gene.
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2008
The intranasal administration of siRNA has opened new vistas in drug delivery and respiratory therapy. In this strategy, synthetic siRNA with or without chemical modifications can be applied intranasally. Various delivery vehicles have been tested and optimized.
Vira Bitko, Sailen Barik
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The intranasal administration of siRNA has opened new vistas in drug delivery and respiratory therapy. In this strategy, synthetic siRNA with or without chemical modifications can be applied intranasally. Various delivery vehicles have been tested and optimized.
Vira Bitko, Sailen Barik
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Detection of siRNAs and miRNAs
2008Small RNAs such as small interfering RNAs (siRNAs) and microRNAs (miRNAs) play crucial roles in establishing general host defense mechanisms against viral infections in plants and the development of disease symptoms. Understanding these fundamental processes requires the sensitive and specific detection of small RNA species.
Kauppinen, S., Havelda, Z.
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