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Liposomal siRNA Delivery
2009 With the recent discovery of small interfering RNA (siRNA), to silence the expression of genes in vitro and in vivo, there has been a need to deliver these molecules to the cell nucleus. Forming a lipid/nucleic acid complex has become a solution and is explored here.Jeffrey, Hughes, Preeti, Yadava, Ryan, Mesaros +2 moreopenaire +2 more sourcesPLGA Microspheres Encapsulating siRNA
2014 The therapeutic use of small interfering RNA (siRNA) represents a new and powerful approach to suppress the expression of pathologically genes. However, biopharmaceutical drawbacks, such as short half-life, poor cellular uptake, and unspecific distribution into the body, hamper the development of siRNA-based therapeutics.DE ROSA, GIUSEPPE, SALZANO, GIUSEPPINAopenaire +3 more sourcesChitosan/siRNA Nanoparticles Encapsulated in PLGA Nanofibers for siRNA Delivery
ACS Nano, 2012 Composite nanofibers of biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) encapsulating chitosan/siRNA nanoparticles (NPs) were prepared by electrospinning. Acidic/alkaline hydrolysis and a bulk/surface degradation mechanism were investigated in order to achieve an optimized release profile for prolonged and efficient gene silencing.Chen, Menglin, Gao, Shan, Dong, Mingdong, Song, Jie, Yang, Chuanxu, Howard, Kenneth Alan, Kjems, Jørgen, Besenbacher, Flemming +7 moreopenaire +2 more sourcessiRNA
2010 Michael M. Morgan, MacDonald J. Christie, Luis De Lecea, Jason C. G. Halford, Josee E. Leysen, Warren H. Meck, Catalin V. Buhusi, Marcy J. Bubar, Kathryn A. Cunningham, Marcy J. Bubar, Kathryn A. Cunningham, Richard W. Foltin, David C. S. Roberts, Andreas Marneros, Andreas Marneros, Alex Hofer, Bart Ellenbroek, Christoph U. Correll, Paul Newhouse, Heather Wilkins, Bart Ellenbroek, Joris C. Verster, Emma Childs, Gary Remington, Edoardo Spina, W. Wolfgang Fleischhacker, John Atack, Hilde Lavreysen, David C. S. Roberts, Sheldon Preskorn, Megan M. Dahmen, Jana Lincoln, Dan J. Stein, Anthony L. Riley, Steve Kohut, Angela Roberts, Marilyn E. Carroll, Peter A. Santi, Stefan Leucht, Klaus A. Miczek, David C. S. Roberts, Eileen M. Joyce, Jonathan P. Roiser, Celia J. A. Morgan, Valerie H. Curran, Mary E. Cain, Michael T. Bardo, Terry E. Robinson, Ian Hindmarch, Marilyn E. Carroll, Peter A. Santi, Marcy J. Bubar, Kathryn A. Cunningham, Darrell D. Mousseau, Andrew Holt, Glen B. Baker, Sidney H. Kennedy, Sakina J. Rizvi, Thomas Steckler, Klaus A. Miczek, Seiya Miyamoto, Sakire Pogun, Gorkem Yararbas, Jill B. Becker, Anders Ågmo, Vera Astreika, Robert Segraves, Rodrigo Andrade, Yogita Chudasama, Roshan Cools, Iván Izquierdo, Lia R. Bevilaqua, Martin Cammarota, Bernard Le Foll, Trevor W. Robbins, Husseini K. Manji, Jorge A. Quiroz, Jos Prickaerts, Bart Ellenbroek, Ennio Esposito, William Invernizzi, Sophie Tambour, John C. Crabbe, Peter J. Flor, Inga D. Neumann, Malcolm Lader, Joseph Zohar, Seithikurippu R. Pandi-Perumal, Milton Kramer, Michael J. Thorpy, Shelby Freedman Harris, D. Warren Spence, Gabriele Fischer, Annemarie Unger, Samuel B. Hutton, Huaiyu Yang, George I. Papakostas, S. Kasper, Frank Sams-Dodd, Yavin Shaham, John R. Mantsch, Craig A. Erickson, David J. Posey, Kelly Blankenship, Kimberly A. Stigler, Christopher J. McDougle, Paul D. Callaghan, Iain S. McGregor, Murray R. Thompson, Frank Sams-Dodd, Klaus A. Miczek, Michel Billiard, Brian A. Fallon, Kelli J. Harding, Daniel Hoyer, Jacques Epelbaum, Cécile Viollet, Cécile Viollet, Jacques Epelbaum, Daniel Hoyer, Mischa de Rover, Sander Nieuwenhuis, Trevor W. Robbins, Stan Floresco, Anne Jackson, Mitul A. Mehta, Johannes Mosbacher, Ronald L. Cowan, Robert Kessler, Peter H. Boeijinga, James Winslow, A. Claudio Cuello, Arthur Christopoulos, Gregory D. Stewart, Patrick M. Sexton, Ashwini Padhi, Naomi A. Fineberg, Sidney H. Kennedy, Sakina J. Rizvi, Mark A. Geyer, Francis C. Colpaert, Celia J. A. Morgan, Valerie H. Curran, Andrew Young, Ronald F. Mucha, Craig A. Erickson, David J. Posey, Kelly Blankenship, Kimberly A. Stigler, Christopher J. McDougle, Christof Baltes, Thomas Mueggler, Markus Rudin, Giovanni Hernandez, Peter Shizgal, Marc N. Branch, Ian P. Stolerman, Sharon Morein-Zamir, Barbara J. Sahakian, Yavin Shaham, Sunila G. Nair, Becky Kinkead, Charles B. Nemeroff, Lucy C. Guillory, John R. Mantsch, Yavin Shaham, R. H. De Rijk, E. R. de Kloet, R. H. De Rijk, E. R. de Kloet, Francisco Aboitiz, Ximena Carrasco, F. Xavier Castellanos, Maria Isabel Colado, A. Richard Green, Suzanne H. Mitchell, Harriet de Wit, Alyson J. Bond, Christine A. Franco, Marc N. Potenza, Caroline Cohen, Marc Turiault, Guy Griebel, Darren R. Christensen, Warren K. Bickel, Michael J. Owens, Chase H. Bourke, Gustavo Turecki, Britta Hahn, Britta Hahn, Sarah Morgan, Angus Mackay, Matthew I. Palmatier, Rick A. Bevins, Lawrence Scahill, Andrea Bari, Stephen B. Dunnett, A. Claudio Cuello, Karim Nader, Oliver Hardt +199 moreopenaire +1 more source
