Results 61 to 70 of about 497,452 (342)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Bio-inspired pulmonary surfactant-modified nanogels : a promising siRNA delivery system [PDF]

, 2015
Inhalation therapy with small interfering RNA (siRNA) is a promising approach in the treatment of pulmonary disorders. However, clinical translation is severely limited by the lack of suitable delivery platforms.
Braeckmans, Kevin, De Backer, Lynn, De Smedt, Stefaan, Demeester, Jo, Raemdonck, Koen, Stuart, Marc CA   +5 more
core   +3 more sources

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9[S]

Journal of Lipid Research, 2011
Reducing circulating LDL-cholesterol (LDL-c) reduces the risk of cardiovascular disease in people with hypercholesterolemia. Current approaches to reduce circulating LDL-c include statins, which inhibit cholesterol synthesis, and ezetimibe, which blocks ...
Brandon Ason, Samnang Tep, Jr. Harry R. Davis, Yiming Xu, Glen Tetzloff, Beverly Galinski, Ferdie Soriano, Natalya Dubinina, Lei Zhu, Alice Stefanni, Kenny K. Wong, Marija Tadin-Strapps, Steven R. Bartz, Brian Hubbard, Mollie Ranalletta, Alan B. Sachs, W. Michael Flanagan, Alison Strack, Nelly A. Kuklin   +18 more
doaj  

Where should siRNAs go: applicable organs for siRNA drugs

Experimental & Molecular Medicine, 2023
AbstractRNA interference mediated by small interfering RNAs (siRNAs) has been exploited for the development of therapeutics. siRNAs can be a powerful therapeutic tool because the working mechanisms of siRNAs are straightforward. siRNAs determine targets based on their sequence and specifically regulate the gene expression of the target gene.
Insook Ahn, Chanhee S. Kang, Jinju Han
openaire   +3 more sources

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2

Molecular Therapy: Nucleic Acids, 2019
Drug combinations can improve the control of diseases involving redundant and highly regulated pathways. Validating a multi-target therapy early in drug development remains difficult.
Radu Mihaila, Dipali Ruhela, Beverly Galinski, Ananda Card, Mark Cancilla, Timothy Shadel, Jing Kang, Samnang Tep, Jie Wei, R. Matthew Haas, Jeremy Caldwell, W. Michael Flanagan, Nelly Kuklin, Elena Cherkaev, Brandon Ason   +14 more
doaj  

Digital modeling by biomedical informatics analysis predicts suppression of COVID-19 infectivity via ‘targeting oligonucleotide-directed devolution’ [PDF]

Exploration of Digital Health Technologies
Aim: Genetic instability represents the hallmark of carcinogenesis. For cancer, the retinoblastoma (RB) gene defect allowing genetic instability was successfully exploited to eliminate cancer.
Frank-Un Hong, Miguel Marciano Castro, Klaus D. Linse   +2 more
doaj   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing

Journal of Lipid Research, 2012
Microsomal triglyceride transfer protein (Mtp) inhibitors represent a novel therapeutic approach to lower circulating LDL cholesterol, although therapeutic development has been hindered by the observed increase in hepatic triglycerides and liver ...
Samnang Tep, Radu Mihaila, Alexander Freeman, Victoria Pickering, Felicia Huynh, Marija Tadin-Strapps, Allison Stracks, Brian Hubbard, Jeremy Caldwell, W. Michael Flanagan, Nelly A. Kuklin, Brandon Ason   +11 more
doaj