Results 101 to 110 of about 100,955 (193)

Epigenetics and immunometabolism in diabetes and aging [PDF]

, 2018
Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation.
Cosentino, Francesco, Guzik, Tomasz J.
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Anti-oxidant and anti-inflammatory activity of ketogenic diet. New perspectives for neuroprotection in alzheimer’s disease [PDF]

, 2018
The ketogenic diet, originally developed for the treatment of epilepsy in non-responder children, is spreading to be used in the treatment of many diseases, including Alzheimer’s disease.
Bonucci, Alessio, Businaro, Rita, Corsi, Mariangela, Maggi, Elisa, Pinto, Alessandro   +4 more
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SIRT1/NOX1 pathway mediated ameliorative effects of rosmarinic acid in folic acid-induced renal injury

Research in Pharmaceutical Sciences
Background and purpose: Renal injury is a serious disorder that can be caused by some diseases or agents. Rosmarinic acid (RA) is a natural and safe compound with powerful antioxidant and anti-inflammatory properties.
Maryam Mottaghi, Akram Eidi, Fatemeh Heidari, Tahereh Komeili Movahhed, Azam Moslehi   +4 more
doaj   +1 more source

Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol [PDF]

, 2013
Sirtuins are NAD+-dependent protein deacetylases regulating metabolism, stress responses and ageing processes. Among the seven mammalian Sirtuins, Sirt1 is the physiologically best-studied isoform.
Curth, Ute, Lakshminarasimhan, Mahadevan, Moniot, Sebastien, Mosalaganti, Shyamal, Raunser, Stefan, Steegborn, Clemens   +5 more
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Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration. [PDF]

, 2015
Background & aimsAll-trans Retinoic acid (RA) regulates hepatic lipid and bile acid homeostasis. Similar to bile acid (BA), RA accelerates partial hepatectomy (PHx)-induced liver regeneration.
Hu, Ying, Liu, Hui-Xin, Wan, Yu-Jui Yvonne   +2 more
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RNAase III-Type Enzyme Dicer Regulates Mitochondrial Fatty Acid Oxidative Metabolism in Cardiac Mesenchymal Stem Cells [PDF]

, 2019
Cardiac mesenchymal stem cells (C-MSC) play a key role in maintaining normal cardiac function under physiological and pathological conditions. Glycolysis and mitochondrial oxidative phosphorylation predominately account for energy production in C-MSC ...
Jin, Yue, Kim, Il-man, Shen, Yan, Su, Xuan, Tang, Yaoliang, Weintraub, Neal L.   +5 more
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Endothelial senescence and microRNA

Biomolecular Concepts, 2012
Cellular senescence occurs when cells lose the ability to divide and proliferate. Endothelial cell senescence is associated with vascular diseases, such as atherosclerosis. In this review, I discuss the factors affecting endothelial cell senescence. Then
Yamakuchi Munekazu
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Intersection between metabolic dysfunction, high fat diet consumption, and brain aging [PDF]

, 2010
Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these ...
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Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus

Diabetes, Metabolic Syndrome and Obesity, 2021
Chunjie Su,1 Qian Cheng,2 Liyun Wang2 1Department of Gastrointestinal Surgery, Jingmen No.1 People’s Hospital, Jingmen, 448000, People’s Republic of China; 2Department of Endocrinology, Yixing People’s Hospital, Yixing, 214200, Jiangsu,
Su C, Cheng Q, Wang L
doaj  

Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NFκB-Dependent Proliferation and Proinflammatory Activation of Macrophages

Cells, 2019
Background: Trypanosoma cruzi (Tc) causes Chagas disease (CD) that is the most frequent cause of heart failure in Latin America. TNF-α+ monocytes/macrophages (Mo/Mφ) are associated with inflammatory pathology in chronic CD.
Xianxiu Wan, Imran Hussain Chowdhury, Zuliang Jie, Subhadip Choudhuri, Nisha Jain Garg   +4 more
doaj   +1 more source