Results 281 to 290 of about 72,220 (305)
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Clinica Chimica Acta, 2014
Cardiovascular disease (CVD) is the leading cause of death worldwide, with aging as the key independent risk factor. Effective interventions are necessary to delay aging. Sirtuin1 (SIRT1), a NAD(+)-dependent histone deacetylase, is closely related to lifespan extension.
Xin-Yuan, Luo +10 more
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Cardiovascular disease (CVD) is the leading cause of death worldwide, with aging as the key independent risk factor. Effective interventions are necessary to delay aging. Sirtuin1 (SIRT1), a NAD(+)-dependent histone deacetylase, is closely related to lifespan extension.
Xin-Yuan, Luo +10 more
openaire +2 more sources
DJ-1 activates SIRT1 through its direct binding to SIRT1
Biochemical and Biophysical Research Communications, 2016The DJ-1 gene is a ras-dependent oncogene and also a causative gene for a familial form of Parkinson's disease park7. DJ-1 is a multi-functional protein and plays roles in regulation of cell growth, cells death, metabolism and mitochondrial homeostasis against oxidative stress.
Kazuko, Takahashi-Niki +6 more
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Current Treatment Options in Oncology
Leukemia is a type of hematological malignancy (HM) caused by uncontrolled proliferation, apoptosis, and differentiation of hematopoietic stem cells (HSCs). Leukemia cells proliferate greatly in the bone marrow (BM), infiltrate other tissues and organs, and affect the normal hematopoietic function.
Zhongqi Wu +4 more
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Leukemia is a type of hematological malignancy (HM) caused by uncontrolled proliferation, apoptosis, and differentiation of hematopoietic stem cells (HSCs). Leukemia cells proliferate greatly in the bone marrow (BM), infiltrate other tissues and organs, and affect the normal hematopoietic function.
Zhongqi Wu +4 more
openaire +2 more sources
Current Pharmaceutical Design, 2009
The intersection between regulatory pathways responsive to metabolic fluctuation on one hand, and to cellular stress on the other, is a fascinating area within which NAD/NADH responsive proteins play a major role [1, 2]. A key player amongst these is SIRT1, a member of the mammalian sirtuin family (SIRT1-7).
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The intersection between regulatory pathways responsive to metabolic fluctuation on one hand, and to cellular stress on the other, is a fascinating area within which NAD/NADH responsive proteins play a major role [1, 2]. A key player amongst these is SIRT1, a member of the mammalian sirtuin family (SIRT1-7).
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Regulation of SIRT1 and Its Roles in Inflammation
Frontiers in Immunology, 2022Ming Chuan Liu +2 more
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Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2
Redox Biology, 2022Junlian Gu +2 more
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SIRT1 promotes DNA repair activity and deacetylation of Ku70
Experimental and Molecular Medicine, 2007Jaemin Jeong +2 more
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C/EBPα regulates SIRT1 expression during adipogenesis
Cell Research, 2010Qiwei Zhai, Chunxi Wang, Zhai Qiwei
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SIRT1 transgenic mice show phenotypes resembling calorie restriction
Aging Cell, 2007Jianyuan Luo, Andrew Steele
exaly