Results 91 to 100 of about 8,557 (169)

Suppression of Hepatocellular Carcinoma by Deletion of SIRT2 in Hepatocytes via Elevated C/EBPβ/GADD45γSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: There is a gap in our understanding of mechanisms promoting hepatocellular carcinoma (HCC), and this limits our ability to provide targeted therapy interventions for HCC.
Fang Wang, Claudia Rose Keating, Yingchen Xu, Wei Hou, Greg Malnassy, Kyle Boedeker, Aldeb Perera, Eugene Ham, Diya Patel, Xianzhong Ding, Wei Qiu   +10 more
doaj   +1 more source

Efficient Generation of Apo Sirt2 Crystals to Facilitate Investigation of Sirt2 Inhibitor Interactions

The selectivity pocket is a key binding site for selective inhibitors of the NAD+-dependent lysine deacylase Sirtuin 2 (Sirt2), a promising drug target due to its involvement in diseases like cancer and neurodegeneration. This pocket typically opens only upon binding of long fatty-acylated substrates or selective inhibitors. While crystal soaking could
Florian Friedrich, Matthias Schiedel, Sören Swyter, Lin Zhang, Wolfgang Sippl, Mike Schutkowski, Oliver Einsle, Manfred Jung   +7 more
openaire   +1 more source

The SIRT2-AMPK axis regulates autophagy induced by acute liver failure

Scientific Reports
This study explores the role of SIRT2 in regulating autophagy and its interaction with AMPK in the context of acute liver failure (ALF). This study investigated the effects of SIRT2 and AMPK on autophagy in ALF mice and TAA-induced AML12 cells.
Qingqi Zhang, Jin Guo, Chunxia Shi, Danmei Zhang, Yukun Wang, Luwen Wang, Zuojiong Gong   +6 more
doaj   +1 more source

Targeting SIRT2 in Aging-Associated Fibrosis Pathophysiology

Aging and disease
Aging is a complex biological process that involves multi-level structural and physiological changes. Aging is a major risk factor for many chronic diseases. The accumulation of senescent cells changes the tissue microenvironment and is closely associated with the occurrence and development of tissue and organ fibrosis.
Huang, Yongjiao, He, Wei, Zhang, Yingting, Zou, Zhihui, Han, Longchuan, Luo, Jing, Wang, Yunqiu, Tang, Xinxin, Li, Yue, Bao, Yuhan, Huang, Ying, Long, Xi-Dai, Fu, Yinkun, He, Ming   +13 more
openaire   +2 more sources

SIRT2 orchestrates the DNA damage response [PDF]

Cell Cycle, 2016
Hui, Zhang, PamelaSara E, Head, David S, Yu   +2 more
openaire   +2 more sources

SIRT2 Gene [PDF]

, 2020
openaire   +1 more source

The anti-proliferative effect of a bergamot juice extract and its flavanones in leukemic THP-1 cell line involves SIRT2

Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche
Plant kingdom provides a wide plethora of remedies which can be exploited to treat prevent and manage human ailments, among which cancer. In these regards, there is consistent supporting evidence of the beneficial properties of Citrus fruits, which are ...
Alessandro Maugeri, Caterina Russo, Laura Musumeci, Michele Navarra   +3 more
doaj   +1 more source

Neuroprotective Effects of Sirt2 Inhibition In Aging

, 2018
Öz bulunamadı.
Aktan, Arzu Keskin, Akbulut, K. Gonca, Akbulut, Hakan   +2 more
openaire   +4 more sources

Multifaceted regulation of sirtuin 2 (Sirt2) deacetylase activity

Journal of Biological Chemistry
Sirtuin 2 (Sirt2) is a member of the sirtuin family of NAD-dependent lysine deacylases and plays important roles in regulation of the cell cycle and gene expression. As a nucleocytoplasmic deacetylase, Sirt2 has been shown to target both histone and nonhistone acetylated protein substrates. The central catalytic domain of Sirt2 is flanked by flexible N
Maheeshi Yapa Abeywardana, Samuel D. Whedon, Kwangwoon Lee, Eunju Nam, Rafael Dovarganes, Sarah DuBois-Coyne, Ishraq A. Haque, Zhipeng A. Wang, Philip A. Cole   +8 more
openaire   +2 more sources

Sirtuin 2 (SIRT2) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source