Results 11 to 20 of about 8,557 (169)
Inhibition of SIRT2 suppresses hepatic fibrosis [PDF]
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2016 Liver fibrosis can progress to cirrhosis and result in serious complications of liver disease. The pathogenesis of liver fibrosis involves the activation of hepatic stellate cells (HSCs), the underlying mechanisms of which are not fully known. Emerging evidence suggests that the classic histone deacetylases play a role in liver fibrosis, but the role ...
Maribel, Arteaga +9 more
openaire +2 more sources
[SIRT2, a multi-talented deacetylase]. [PDF]
Medecine sciences : M/S, 2014 Sirtuin 2 (SIRT2) is an NAD(+) (nicotinamide adenine dinucleotide)-dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context. The natural polyphenol resveratrol is known to exert opposite actions on neural cells according to their normal or cancerous status.
Sayd, Salwa +2 more
openaire +3 more sources
SIRT2, tubulin deacetylation, and oligodendroglia differentiation [PDF]
Cell Motility, 2007 AbstractThe mammalian silent information regulator 2 (SIRT2) is an NAD‐dependent histone deacetylase with known roles in the regulation of the cell cycle. SIRT2 is also a tubulin deacetylase functioning as an early mitotic checkpoint, but its roles in regulating cytoplasmic microtubule dynamics were unknown.
Bor Luen, Tang, Christelle En Lin, Chua
openaire +2 more sources
SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation [PDF]
Cell Reports, 2021 The breast cancer type I susceptibility protein (BRCA1) and BRCA1-associated RING domain protein I (BARD1) heterodimer promote genome integrity through pleiotropic functions, including DNA double-strand break (DSB) repair by homologous recombination (HR).
Elizabeth V. Minten +5 more
openaire +3 more sources
Cell Death and Disease, 2022 Osteosarcomas (OS) are highly metastatic and usually lead to poor outcomes. Epithelial-mesenchymal transition (EMT) is reported to be a critical event in metastasis. SIRT2 exerts dual functions in many different tumors.
Yonghao Tian +5 more
doaj +1 more source
Role of SIRT2 in Regulation of Stemness of Cancer Stem-Like Cells in Renal Cell Carcinoma
Cellular Physiology and Biochemistry, 2018 Background/Aims: Cancer stem cells (CSCs) contribute to tumorgenesis, invasion and metastasis, and are typically resistant to chemotherapy. Recent reports showed that SIRT2 was upregulated in several cancers. However, whether SIRT2 may be a CSC marker in
Ruojing Wei, Dalin He, Xinshi Zhang
doaj +1 more source
Molecules, 2020 Genetic ablation as well as pharmacological inhibition of sirtuin 2 (SIRT2), an NAD+-dependent protein deacylase, have therapeutic effects in various cancers and neurodegenerative diseases.
Sarwat Chowdhury +8 more
doaj +1 more source
Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2
Cellular Physiology and Biochemistry, 2018 Background/Aims: Renal tubular epithelial cells and fibroblasts are the main sources of myofibroblasts, and these cells produce the extracellular matrix during tubulointerstitial fibrosis (TIF).
Fang-Fang He +6 more
doaj +1 more source
Technology in Cancer Research & Treatment, 2020 Objective: The present study aimed to explore the function of sirtuin 2 (SIRT2) on cell proliferation, apoptosis, rat sarcoma virus (RAS)/ extracellular signal-regulated kinase (ERK) pathway in endometrial cancer (EC).
Yanjuan Guo MD +4 more
doaj +1 more source
Scientific Reports, 2021 Sirtuin 2 (Sirt2) nicotinamide adenine dinucleotide-dependent deacetylase enzyme has been reported to alter diverse biological functions in the cells and onset of diseases, including cancer, aging, and neurodegenerative diseases, which implicate the ...
Shiv Bharadwaj +5 more
doaj +1 more source